Self-Healing Hydrogels: Development, Biomedical Applications, and Challenges.
drug delivery
hydrogel
mechanical properties
modulus
self-healing
tissue engineering
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
26 Oct 2022
26 Oct 2022
Historique:
received:
29
09
2022
revised:
19
10
2022
accepted:
23
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
12
11
2022
Statut:
epublish
Résumé
Polymeric hydrogels have drawn considerable attention as a biomedical material for their unique mechanical and chemical properties, which are very similar to natural tissues. Among the conventional hydrogel materials, self-healing hydrogels (SHH) are showing their promise in biomedical applications in tissue engineering, wound healing, and drug delivery. Additionally, their responses can be controlled via external stimuli (e.g., pH, temperature, pressure, or radiation). Identifying a suitable combination of viscous and elastic materials, lipophilicity and biocompatibility are crucial challenges in the development of SHH. Furthermore, the trade-off relation between the healing performance and the mechanical toughness also limits their real-time applications. Additionally, short-term and long-term effects of many SHH in the in vivo model are yet to be reported. This review will discuss the mechanism of various SHH, their recent advancements, and their challenges in tissue engineering, wound healing, and drug delivery.
Identifiants
pubmed: 36365532
pii: polym14214539
doi: 10.3390/polym14214539
pmc: PMC9654449
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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