RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
29 10 2022
Historique:
received: 26 09 2022
revised: 24 10 2022
accepted: 28 10 2022
entrez: 11 11 2022
pubmed: 12 11 2022
medline: 15 11 2022
Statut: epublish

Résumé

It is important to understand the features affecting virus replication, fitness, and transmissibility as they contribute to the outcome of infection and affect disease intervention approaches. Respiratory syncytial virus (RSV) is a major contributor to respiratory disease, particularly in the infant and elderly populations. Although first described over 60 years ago, there are no approved vaccines and there are limited specific antiviral treatments due in part to our incomplete understanding of the features affecting RSV replication, immunity, and disease. RSV studies have typically focused on using continuous cell lines and conventional RSV strains to establish vaccine development and various antiviral countermeasures. This review outlines how the RSV G protein influences viral features, including replication, transmission, and disease, and how understanding the role of the G protein can improve the understanding of preclinical studies.

Identifiants

pubmed: 36366494
pii: v14112396
doi: 10.3390/v14112396
pmc: PMC9692685
pii:
doi:

Substances chimiques

Respiratory Syncytial Virus Vaccines 0
Antiviral Agents 0
GTP-Binding Proteins EC 3.6.1.-
Antibodies, Viral 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Harrison C Bergeron (HC)

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30605, USA.

Ralph A Tripp (RA)

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30605, USA.

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