Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.
hepatitis B core protein
hepatitis B surface antigen
hepatitis B virus
importin α/β
ivermectin
karyopherin α
nuclear localization signal
nuclear transfer
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
08 11 2022
08 11 2022
Historique:
received:
21
09
2022
revised:
28
10
2022
accepted:
04
11
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Hepatitis B virus (HBV) specifically infects human hepatocytes and increases the risks of cirrhosis and liver cancer. Currently, nucleic acid analogs are the main therapeutics for chronic hepatitis caused by HBV infection. Although nucleic acid analogs can eliminate HBV DNA by inhibiting HBV reverse transcriptase, they cannot lead to negative conversion of covalently closed circular DNA (cccDNA) and hepatitis B surface antigen (HBsAg). In this study, we revealed that the antifilarial drug ivermectin suppresses HBV production by a different mechanism from the nucleic acid analog entecavir or Na
Identifiants
pubmed: 36366568
pii: v14112468
doi: 10.3390/v14112468
pmc: PMC9695645
pii:
doi:
Substances chimiques
Hepatitis B Surface Antigens
0
karyopherin alpha 2
0
Ivermectin
70288-86-7
DNA, Circular
0
DNA, Viral
0
KPNA2 protein, human
0
alpha Karyopherins
0
KPNA1 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Hepatology. 2016 Jan;63(1):261-83
pubmed: 26566064
J Virol. 2010 Jan;84(1):387-96
pubmed: 19864387
Drug Metab Dispos. 2018 Nov;46(11):1519-1527
pubmed: 30158250
Curr Biol. 1995 Apr 1;5(4):383-92
pubmed: 7627554
FEBS J. 2015 Feb;282(3):445-62
pubmed: 25429850
J Antibiot (Tokyo). 2017 May;70(5):495-505
pubmed: 28196978
Hepatol Int. 2016 Jan;10(1):1-98
pubmed: 26563120
Antimicrob Agents Chemother. 2019 Dec 20;64(1):
pubmed: 31658963
Hepatology. 2016 May;63(5):1481-92
pubmed: 27100145
Viruses. 2022 Jun 26;14(7):
pubmed: 35891374
J Virol. 2015 Dec;89(23):11945-53
pubmed: 26378168
Viruses. 2022 Feb 21;14(2):
pubmed: 35216027
Cochrane Database Syst Rev. 2018 Apr 02;4:CD012994
pubmed: 29608022
Viruses. 2017 Mar 21;9(3):
pubmed: 28335554
J Virol. 1991 Feb;65(2):575-82
pubmed: 1987370
Semin Liver Dis. 2005;25 Suppl 1:3-8
pubmed: 16103976
N Engl J Med. 2004 Sep 16;351(12):1206-17
pubmed: 15371578
Vet Hum Toxicol. 2000 Feb;42(1):30-5
pubmed: 10670084
J Biol Chem. 2007 Feb 23;282(8):5101-5
pubmed: 17170104
Cell. 1986 Nov 7;47(3):451-60
pubmed: 3768961
Biochim Biophys Acta. 2012 Jun;1819(6):616-30
pubmed: 22326858
Mol Cell Biol. 1983 Oct;3(10):1766-73
pubmed: 6646122
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9849-54
pubmed: 12909718
Viruses. 2022 Apr 06;14(4):
pubmed: 35458494
Lancet. 2018 Nov 24;392(10161):2313-2324
pubmed: 30496122
Cell. 1995 Dec 1;83(5):683-92
pubmed: 8521485
Lancet. 2005 Jan 8-14;365(9454):123-9
pubmed: 15639293
Elife. 2012 Nov 13;1:e00049
pubmed: 23150796
Clin Liver Dis. 2007 Nov;11(4):685-706, vii
pubmed: 17981225
J Med Virol. 2004 Feb;72(2):223-9
pubmed: 14695663
J Viral Hepat. 2019 Jul;26(7):786-794
pubmed: 30803126
Biochim Biophys Acta. 2015 Aug;1853(8):1870-8
pubmed: 25960398
Sci Rep. 2022 Feb 8;12(1):2133
pubmed: 35136096
Gastroenterology. 2012 May;142(5):1140-1149.e3; quiz e13-4
pubmed: 22333950
Biochem J. 2012 May 1;443(3):851-6
pubmed: 22417684
Virology. 2015 May;479-480:672-86
pubmed: 25759099
Cochrane Database Syst Rev. 2016 Jan 18;(1):CD007745
pubmed: 26778150
Gastroenterology. 2004 Jun;126(7):1750-8
pubmed: 15188170
Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8487-8492
pubmed: 30952782
J Hepatol. 2009 Sep;51(3):581-92
pubmed: 19616338
Aliment Pharmacol Ther. 2019 Apr;49(8):1060-1070
pubmed: 30828831
Antiviral Res. 2018 Nov;159:55-62
pubmed: 30266338
Hepatology. 2009 May;49(5 Suppl):S174-84
pubmed: 19399794
Proc Jpn Acad Ser B Phys Biol Sci. 2018;94(7):259-274
pubmed: 30078827
Structure. 2015 Feb 3;23(2):374-84
pubmed: 25599645
Virology. 2020 Sep;548:31-38
pubmed: 32838944
BMC Cell Biol. 2010 Aug 11;11:63
pubmed: 20701745
PLoS Pathog. 2012 Jan;8(1):e1002488
pubmed: 22275867
N Engl J Med. 2005 Jun 30;352(26):2682-95
pubmed: 15987917
J Virol. 2018 Nov 12;92(23):
pubmed: 30209178
Hepatology. 2009 May;49(5 Suppl):S13-21
pubmed: 19399811
Biochem Biophys Res Commun. 2014 Jan 17;443(3):808-13
pubmed: 24342612
Hepatology. 2006 Oct;44(4):915-24
pubmed: 17006908
BMC Infect Dis. 2014 Dec 03;14:608
pubmed: 25465805
J Hepatol. 2018 Dec;69(6):1231-1241
pubmed: 30142426
J Virol. 2007 May;81(10):5284-93
pubmed: 17344301
Hepatology. 2014 May;59(5):1726-37
pubmed: 24375637
J Hepatol. 2017 Aug;67(2):370-398
pubmed: 28427875
Biochem Biophys Res Commun. 2014 Sep 26;452(3):315-21
pubmed: 25150444
Science. 1983 Aug 26;221(4613):823-8
pubmed: 6308762
Nature. 2011 Jun 2;474(7349):54-60
pubmed: 21572436
Sci Rep. 2018 Feb 26;8(1):3626
pubmed: 29483619
Cochrane Database Syst Rev. 2016 Jan 15;(1):CD011146
pubmed: 26771164