Rescuing Cardiac Cells and Improving Cardiac Function by Targeted Delivery of Oxygen-Releasing Nanoparticles after or Even before Acute Myocardial Infarction.
acute myocardial infarction
controlled release of oxygen
myocardial repair
nanoparticles
targeted delivery
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
22 11 2022
22 11 2022
Historique:
pubmed:
12
11
2022
medline:
30
11
2022
entrez:
11
11
2022
Statut:
ppublish
Résumé
Myocardial infarction (MI) causes massive cell death due to restricted blood flow and oxygen deficiency. Rapid and sustained oxygen delivery following MI rescues cardiac cells and restores cardiac function. However, current oxygen-generating materials cannot be administered during acute MI stage without direct injection or suturing methods, both of which risk rupturing weakened heart tissue. Here, we present infarcted heart-targeting, oxygen-releasing nanoparticles capable of being delivered by intravenous injection at acute MI stage, and specifically accumulating in the infarcted heart. The nanoparticles can also be delivered before MI, then gather at the injured area after MI. We demonstrate that the nanoparticles, delivered either pre-MI or post-MI, enhance cardiac cell survival, stimulate angiogenesis, and suppress fibrosis without inducing substantial inflammation and reactive oxygen species overproduction. Our findings demonstrate that oxygen-delivering nanoparticles can provide a nonpharmacological solution to rescue the infarcted heart during acute MI and preserve heart function.
Identifiants
pubmed: 36367231
doi: 10.1021/acsnano.2c10043
pmc: PMC9930176
mid: NIHMS1869976
doi:
Substances chimiques
Oxygen
S88TT14065
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
19551-19566Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL138353
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL164062
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK133949
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB022018
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138175
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056919
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL153262
Pays : United States
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