Molecular testing in cytology.
cytology samples
molecular testing
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
21
10
2022
accepted:
22
10
2022
pubmed:
12
11
2022
medline:
15
12
2022
entrez:
11
11
2022
Statut:
ppublish
Résumé
In the era of personalized medicine, molecular testing plays a critical role in patient care. The rapid advance of molecular techniques, especially next-generation sequencing, makes molecular diagnosis feasible in daily practice. Molecular testing can be used as a valuable ancillary test to increase diagnostic sensitivity and specificity, especially in small biopsy or cytology samples. In addition, molecular testing plays an important role in selecting patients for appropriate treatment by detecting therapeutic and predictive biomarkers in tissue or cytology samples. Molecular studies can be applied in all cytology samples, sometimes with better results than histology. As molecular testing has become essential for patient care and is often requested to be performed in cytology samples, it is critical for cytopathologists to understand the basics of molecular diagnostic methods, indications for molecular testing, and how to best utilize different cytologic samples for this purpose. In this special issue, experts in various areas of cytopathology and molecular pathology review the literature and discuss the basics of molecular techniques and the application of molecular testing in various types of cytology samples. It is our hope that after reading the articles in this special issue, the readers can know better about the possibilities of molecular cytology, a very exciting field of pathology.
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-4Informations de copyright
© 2022 Wiley Periodicals LLC.
Références
Salto-Tellez M. Diagnostic molecular cytopathology - a further decade of progress. Cytopathology. 2015;26(5):269-270.
Cheng DT, Mitchell TN, Zehir A, et al. Memorial Sloan Kettering-integrated mutation profiling of actionable cancer targets (MSK-IMPACT): a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology. J Mol Diagn. 2015;17(3):251-264.
Frampton GM, Fichtenholtz A, Otto GA, et al. Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nat Biotechnol. 2013;31(11):1023-1031.
Sanchez A, Bocklage T. Precision cytopathology: expanding opportunities for biomarker testing in cytopathology. J Am Soc Cytopathol. 2019;8(2):95-115.
Roy-Chowdhuri S, Pisapia P, Salto-Tellez M, et al. Invited review-next-generation sequencing: a modern tool in cytopathology. Virchows Arch. 2019;475(1):3-11.
Pisapia P, Pepe F, Sgariglia R, et al. Next generation sequencing in cytology. Cytopathology. 2021;32(5):588-595.
Turner SA, Shaar RA, Yang Z. The basics of commonly used molecular techniques for diagnosis, and application of molecular testing in cytology. Diagn Cytopathol. 2023;51(1):83-94.
Schmitt F, Lozano MD. Molecular/biomarker testing in lung cytology: a practical approach. Diagn Cytopathol. 2023;51(1):59-67.
Fernández Aceñero MJ, Díaz Del Arco C, Dinarés C, et al. Overview and update on molecular testing in non-small cell lung carcinoma utilizing endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) samples. Diagn Cytopathol. 2023;51(1):26-35.
Layfield LJ, Zhang T, Esebua M. PD-L1 immunohistochemical testing: a review with reference to cytology specimens. Diagn Cytopathol. 2023;51(1):51-58.
McMurtry V, Canberk S, Deftereos G. Molecular testing in fine-needle aspiration of thyroid nodules. Diagn Cytopathol. 2023;51(1):36-50.
Rottmann D, Abdulfatah E, Pantanowitz L. Molecular testing of soft tissue tumors. Diagn Cytopathol. 2023;51(1):12-25.
Layfield LJ, Zhang T, Esebua M. Molecular features of pancreaticobiliary neoplasms: implications for diagnosis, prognostication, and therapy selection. Diagn Cytopathol. 2023;51(1):5-11.
Caruso CR, Yang Z. Molecular diagnostics of infectious disease: detection and characterization of microbial agents in cytology samples. Diagn Cytopathol. 2023;51(1):68-82.