Safety of COVID-19 Pfizer-BioNtech (BNT162b2) mRNA vaccination in adolescents aged 12-17 years: A systematic review and meta-analysis.
COVID-19
Pandemic
SARS-CoV-2
adolescents
global surveillance
immunization
youth
Journal
Human vaccines & immunotherapeutics
ISSN: 2164-554X
Titre abrégé: Hum Vaccin Immunother
Pays: United States
ID NLM: 101572652
Informations de publication
Date de publication:
30 Nov 2022
30 Nov 2022
Historique:
pubmed:
12
11
2022
medline:
15
12
2022
entrez:
11
11
2022
Statut:
ppublish
Résumé
The COVID-19 pandemic has severely affected adolescents. Safe and effective vaccines are pivotal tools in controlling this pandemic. We reviewed the safety profile of the BNT162b2 COVID-19 vaccine in adolescents using mostly real-world data to assist decision-making. We used random-effects model meta-analysis to derive pooled rates of single or grouped adverse events following immunization (AEFI) after each primary and booster dose, as well as after combining all doses. Reporting on over one million participants with safety data were included. The most-reported local and systemic AEFIs were pain/swelling/erythema/redness and fatigue/headache/myalgia, respectively. AESIs were rarely reported but were more frequent after the second dose than they were after the first and the booster doses. Health impact was less common among adolescents after receiving BNT162b2 vaccine. Rare life-threatening AEFIs were reported across all doses in real-world studies. Our findings highlight the significance of enhancing national and regional vaccination programs to ensure public confidence.
Identifiants
pubmed: 36367429
doi: 10.1080/21645515.2022.2144039
pmc: PMC9746476
doi:
Substances chimiques
BNT162 Vaccine
0
RNA, Messenger
0
COVID-19 Vaccines
0
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2144039Références
Respir Investig. 2022 Mar;60(2):248-255
pubmed: 34920980
Vaccine. 2022 Jan 31;40(5):691-694
pubmed: 35012777
Am J Prev Med. 2021 Jan;60(1 Suppl 1):S77-S86
pubmed: 33189502
Vaccines (Basel). 2022 May 09;10(5):
pubmed: 35632500
Nat Med. 2021 Feb;27(2):225-228
pubmed: 33082575
Hum Vaccin Immunother. 2019;15(7-8):1615-1627
pubmed: 30633623
Nat Med. 2022 May;28(5):1050-1062
pubmed: 35177862
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
J Travel Med. 2021 Oct 11;28(7):
pubmed: 34128049
Lancet Child Adolesc Health. 2022 May;6(5):294-302
pubmed: 35189083
JAMA Netw Open. 2021 Aug 2;4(8):e2122255
pubmed: 34463744
N Engl J Med. 2021 Jul 15;385(3):239-250
pubmed: 34043894
Stat Med. 2002 Jun 15;21(11):1539-58
pubmed: 12111919
JAMA. 2021 Oct 12;326(14):1390-1399
pubmed: 34477808
Res Synth Methods. 2019 Sep;10(3):476-483
pubmed: 30945438
Nat Med. 2021 Aug;27(8):1385-1394
pubmed: 34272499
Vaccines (Basel). 2022 Feb 25;10(3):
pubmed: 35334991
MMWR Morb Mortal Wkly Rep. 2021 Dec 31;70(5152):1755-1760
pubmed: 34968370
MMWR Morb Mortal Wkly Rep. 2022 Mar 04;71(9):347-351
pubmed: 35239637
J Med Internet Res. 2021 Jun 11;23(6):e27632
pubmed: 34061757
Stat Med. 1998 Apr 30;17(8):857-72
pubmed: 9595616
N Engl J Med. 2021 Nov 4;385(19):1761-1773
pubmed: 34525277
Front Public Health. 2021 Oct 13;9:752323
pubmed: 34722451
Emerg Microbes Infect. 2022 Dec;11(1):885-893
pubmed: 35254219
Lancet Infect Dis. 2022 Jan;22(1):64-72
pubmed: 34411532
BMJ. 2016 Oct 12;355:i4919
pubmed: 27733354
Expert Rev Vaccines. 2018 Dec;17(12):1063-1070
pubmed: 30451037
MMWR Morb Mortal Wkly Rep. 2022 Apr 08;71(14):517-523
pubmed: 35389977
JAMA Pediatr. 2022 Mar 01;176(3):e216436
pubmed: 35044430
Vaccine. 2019 Oct 8;37(43):6317-6323
pubmed: 31521412
Vaccines (Basel). 2021 Feb 19;9(2):
pubmed: 33669659
Pathog Glob Health. 2022 Jun;116(4):236-243
pubmed: 34928187
BMJ. 2011 Oct 18;343:d5928
pubmed: 22008217
Lancet Child Adolesc Health. 2021 Oct;5(10):708-718
pubmed: 34358472
Clin Mol Allergy. 2022 Jan 17;20(1):1
pubmed: 35039051
Vaccines (Basel). 2022 Jan 24;10(2):
pubmed: 35214638
Vaccine. 2018 Feb 14;36(8):1072-1077
pubmed: 29358055
Nature. 2021 Apr;592(7853):283-289
pubmed: 33524990
Vaccines (Basel). 2021 Nov 09;9(11):
pubmed: 34835228
Clin Infect Dis. 2022 Apr 28;74(8):1429-1441
pubmed: 34272559
Euro Surveill. 2020 Jun;25(25):
pubmed: 32613939
J Infect Chemother. 2022 Apr;28(4):576-581
pubmed: 35058126
Lancet Reg Health Eur. 2022 Jan;12:100253
pubmed: 34729549
Lancet Child Adolesc Health. 2022 Apr;6(4):230-239
pubmed: 35143770
Rev Esc Enferm USP. 2014 Aug;48(4):739-47
pubmed: 25338257
Int J Environ Res Public Health. 2021 Sep 28;18(19):
pubmed: 34639527
Int J Infect Dis. 2022 Mar;116:47-50
pubmed: 34965462