A Review of Radiation-Induced Alterations of Multi-Omic Profiles, Radiation Injury Biomarkers, and Countermeasures.
Journal
Radiation research
ISSN: 1938-5404
Titre abrégé: Radiat Res
Pays: United States
ID NLM: 0401245
Informations de publication
Date de publication:
01 01 2023
01 01 2023
Historique:
received:
29
09
2021
accepted:
24
10
2022
pubmed:
12
11
2022
medline:
12
1
2023
entrez:
11
11
2022
Statut:
ppublish
Résumé
Increasing utilization of nuclear power enhances the risks associated with industrial accidents, occupational hazards, and the threat of nuclear terrorism. Exposure to ionizing radiation interferes with genomic stability and gene expression resulting in the disruption of normal metabolic processes in cells and organs by inducing complex biological responses. Exposure to high-dose radiation causes acute radiation syndrome, which leads to hematopoietic, gastrointestinal, cerebrovascular, and many other organ-specific injuries. Altered genomic variations, gene expression, metabolite concentrations, and microbiota profiles in blood plasma or tissue samples reflect the whole-body radiation injuries. Hence, multi-omic profiles obtained from high-resolution omics platforms offer a holistic approach for identifying reliable biomarkers to predict the radiation injury of organs and tissues resulting from radiation exposures. In this review, we performed a literature search to systematically catalog the radiation-induced alterations from multi-omic studies and radiation countermeasures. We covered radiation-induced changes in the genomic, transcriptomic, proteomic, metabolomic, lipidomic, and microbiome profiles. Furthermore, we have covered promising multi-omic biomarkers, FDA-approved countermeasure drugs, and other radiation countermeasures that include radioprotectors and radiomitigators. This review presents an overview of radiation-induced alterations of multi-omics profiles and biomarkers, and associated radiation countermeasures.
Identifiants
pubmed: 36368026
pii: 488358
doi: 10.1667/RADE-21-00187.1
pmc: PMC10279411
mid: NIHMS1907939
doi:
Substances chimiques
Radiation-Protective Agents
0
Biomarkers
0
Types de publication
Review
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-111Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM113126
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119770
Pays : United States
Informations de copyright
© 2023 by Radiation Research Society. All rights of reproduction in any form reserved.
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