Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 11 2022
11 11 2022
Historique:
received:
05
01
2022
accepted:
26
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
16
11
2022
Statut:
epublish
Résumé
Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori from East Asia, which have undergone little admixture, have accumulated many more non-synonymous mutations than African strains. European and Middle Eastern bacteria have elevated African ancestry at the sites of these mutations, implying selection to remove them during admixture. Simulations show that population fitness can be restored after bottlenecks by migration and subsequent admixture of small numbers of bacteria from non-bottlenecked populations. We conclude that recent spread of African DNA has been driven by deleterious mutations accumulated during the original out-of-Africa bottleneck.
Identifiants
pubmed: 36369175
doi: 10.1038/s41467-022-34475-3
pii: 10.1038/s41467-022-34475-3
pmc: PMC9652371
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6842Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
Références
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5033-8
pubmed: 21383187
Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):17758-64
pubmed: 23077256
Genetics. 1963 Oct;48:1303-12
pubmed: 14071753
Helicobacter. 2017 Aug;22(4):
pubmed: 28271597
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Mol Biol Evol. 2019 May 1;36(5):1101-1109
pubmed: 30590560
Genetics. 2012 Nov;192(3):1065-93
pubmed: 22960212
Bioinformatics. 2016 Oct 1;32(19):3047-8
pubmed: 27312411
Genetics. 2015 Jul;200(3):947-63
pubmed: 25995212
Mol Biol Evol. 2022 Feb 3;39(2):
pubmed: 35022759
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13880-5
pubmed: 23898187
Science. 2003 Mar 7;299(5612):1582-5
pubmed: 12624269
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12619-24
pubmed: 9770535
Curr Opin Genet Dev. 2016 Dec;41:150-158
pubmed: 27744216
PLoS Genet. 2018 Oct 22;14(10):e1007741
pubmed: 30346959
Nature. 2008 Feb 21;451(7181):994-7
pubmed: 18288194
Mol Biol Evol. 2000 Jan;17(1):32-43
pubmed: 10666704
G3 (Bethesda). 2014 Feb 19;4(2):325-39
pubmed: 24347631
Science. 2014 Feb 14;343(6172):747-751
pubmed: 24531965
PLoS Pathog. 2008 Oct;4(10):e1000180
pubmed: 18949030
Mol Biol Evol. 2007 Aug;24(8):1586-91
pubmed: 17483113
Science. 2016 Jan 8;351(6269):162-165
pubmed: 26744403
Science. 2018 May 11;360(6389):656-660
pubmed: 29674434
PLoS Genet. 2010 Jul 22;6(7):e1001036
pubmed: 20661309
Mol Biol Evol. 2013 Jun;30(6):1454-64
pubmed: 23505045
Evolution. 1995 Dec;49(6):1067-1080
pubmed: 28568521
Annu Rev Genet. 1982;16:1-19
pubmed: 6760797
Mutat Res. 1964 May;106:2-9
pubmed: 14195748
Microbiology (Reading). 2000 Apr;146 ( Pt 4):851-860
pubmed: 10784043
PLoS Genet. 2012;8(11):e1002967
pubmed: 23166502
J Integr Bioinform. 2013 Nov 15;10(3):233
pubmed: 24231147
Genetics. 2016 Jun;203(2):881-91
pubmed: 27038113
PLoS Pathog. 2012;8(5):e1002693
pubmed: 22589724
Microb Genom. 2022 Feb;8(2):
pubmed: 35188454
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15056-61
pubmed: 11742075
PLoS Genet. 2012 Jan;8(1):e1002453
pubmed: 22291602
PLoS Genet. 2017 Apr 14;13(4):e1006730
pubmed: 28410409
N Engl J Med. 2002 Oct 10;347(15):1175-86
pubmed: 12374879
PLoS Biol. 2007 Apr;5(4):e94
pubmed: 17407380
PLoS Genet. 2016 Jan 11;12(1):e1005774
pubmed: 26752180
PLoS One. 2013;8(1):e55120
pubmed: 23383074
Bioinformatics. 2014 Jul 15;30(14):2068-9
pubmed: 24642063
Mol Biol Evol. 2014 Jul;31(7):1929-36
pubmed: 24739305
Nature. 2007 Feb 22;445(7130):915-918
pubmed: 17287725