Sexually dimorphic architecture and function of a mechanosensory circuit in C. elegans.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 11 2022
11 11 2022
Historique:
received:
10
02
2022
accepted:
01
11
2022
pubmed:
13
11
2022
medline:
16
11
2022
entrez:
12
11
2022
Statut:
epublish
Résumé
How sensory perception is processed by the two sexes of an organism is still only partially understood. Despite some evidence for sexual dimorphism in auditory and olfactory perception, whether touch is sensed in a dimorphic manner has not been addressed. Here we find that the neuronal circuit for tail mechanosensation in C. elegans is wired differently in the two sexes and employs a different combination of sex-shared sensory neurons and interneurons in each sex. Reverse genetic screens uncovered cell- and sex-specific functions of the alpha-tubulin mec-12 and the sodium channel tmc-1 in sensory neurons, and of the glutamate receptors nmr-1 and glr-1 in interneurons, revealing the underlying molecular mechanisms that mediate tail mechanosensation. Moreover, we show that only in males, the sex-shared interneuron AVG is strongly activated by tail mechanical stimulation, and accordingly is crucial for their behavioral response. Importantly, sex reversal experiments demonstrate that the sexual identity of AVG determines both the behavioral output of the mechanosensory response and the molecular pathways controlling it. Our results present extensive sexual dimorphism in a mechanosensory circuit at both the cellular and molecular levels.
Identifiants
pubmed: 36369281
doi: 10.1038/s41467-022-34661-3
pii: 10.1038/s41467-022-34661-3
pmc: PMC9652301
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
TMC-1 protein, C elegans
0
Ion Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6825Informations de copyright
© 2022. The Author(s).
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