In vitro metabolism of the new antifungal dapaconazole using liver microsomes.

Male Animals Rats Humans Dogs Microsomes, Liver / metabolism Tandem Mass Spectrometry / methods Antifungal Agents Rats, Sprague-Dawley Chromatography, High Pressure Liquid / methods Imidazoles / metabolism
Cytochrome P450 Dapaconazole In vitro metabolism LC-MS/MS Microsomes

Journal

Drug metabolism and pharmacokinetics
ISSN: 1880-0920
Titre abrégé: Drug Metab Pharmacokinet
Pays: England
ID NLM: 101164773

Informations de publication

Date de publication:
Dec 2022
Historique:
received: 25 04 2022
revised: 26 06 2022
accepted: 08 09 2022
pubmed: 13 11 2022
medline: 6 12 2022
entrez: 12 11 2022
Statut: ppublish

Résumé

Dapaconazole is a new antifungal imidazole that has been shown a high efficacy against several pathogenic fungi. This study aimed to investigate the interspecies variation in the in vitro metabolic profiles and in vivo hepatic clearance (CL

Identifiants

DOI: 10.1016/j.dmpk.2022.100475 PMID: 36370616
pubmed: 36370616
pii: S1347-4367(22)00032-5
doi: 10.1016/j.dmpk.2022.100475
pii:
doi:

Substances chimiques

Antifungal Agents 0
1-(2-(2,4-dichlorophenyl)-2-(4-(trifluoromethyl)benzyloxy)ethyl)-1H-imidazole 0
Imidazoles 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

100475

Informations de copyright

Copyright © 2022 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflicts of interest.

Auteurs

Natalícia de Jesus Antunes (NJ)

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: nataliciaja@gmail.com.

Gemma Coombes (G)

Analytical Services International (ASI) Ltd., St George's - University of London, Cranmer Terrace, London, SW17 0RE, UK.

Kelly Francisco da Cunha (KF)

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil; Campinas Poison Control Center, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.

Fernanda de Lima Moreira (FL)

Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Alan C Pilon (AC)

NPPNS, Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.

Norberto Peporine Lopes (NP)

NPPNS, Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.

José Luiz da Costa (JLD)

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil; Campinas Poison Control Center, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.

Karin Kipper (K)

Institute of Chemistry, University of Tartu, 14a Ravila Street, 50411, Tartu, Estonia.

Lewis Couchman (L)

Analytical Services International (ASI) Ltd., St George's - University of London, Cranmer Terrace, London, SW17 0RE, UK; Pharmaceutical Sciences Clinical Academic Group, King's College London, London, United Kingdom.

Atholl Johnston (A)

Analytical Services International (ASI) Ltd., St George's - University of London, Cranmer Terrace, London, SW17 0RE, UK; Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Gilberto De Nucci (G)

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil; Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › In vitro metabolism of the new antifungal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › In vitro metabolism of the new antifungal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › In vitro metabolism of the new antifungal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › In vitro metabolism of the new antifungal...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › In vitro metabolism of the new antifungal...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › In vitro metabolism of the new antifungal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › In vitro metabolism of the new antifungal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › In vitro metabolism of the new antifungal...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › In vitro metabolism of the new antifungal...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › In vitro metabolism of the new antifungal...