Dysphagia for medication in Parkinson's disease.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
12 Nov 2022
12 Nov 2022
Historique:
received:
01
05
2022
accepted:
26
10
2022
entrez:
12
11
2022
pubmed:
13
11
2022
medline:
13
11
2022
Statut:
epublish
Résumé
Dysphagia is common in Parkinson's disease (PD) and is assumed to complicate medication intake. This study comprehensively investigates dysphagia for medication and its association with motor complications in PD. Based on a retrospective analysis, a two-dimensional and graduated classification of dysphagia for medication was introduced differentiating swallowing efficiency and swallowing safety. In a subsequent prospective study, sixty-six PD patients underwent flexible endoscopic evaluation of swallowing, which included the swallowing of 2 tablets and capsules of different sizes. Dysphagia for medication was present in nearly 70% of PD patients and predicted motor complications according to the MDS-UPDRS-part-IV in a linear regression model. Capsules tended to be swallowed more efficiently compared to tablets, irrespective of size. A score of ≥1 on the swallow-related-MDS-UPDRS-items can be considered an optimal cut-off to predict dysphagia for medication. Swallowing impairment for oral medication may predispose to motor complications.
Identifiants
pubmed: 36371409
doi: 10.1038/s41531-022-00421-9
pii: 10.1038/s41531-022-00421-9
pmc: PMC9653428
doi:
Types de publication
Journal Article
Langues
eng
Pagination
156Informations de copyright
© 2022. The Author(s).
Références
Int J Clin Pharm. 2013 Dec;35(6):1130-6
pubmed: 23963541
J Clin Hosp Pharm. 1981 Sep;6(3):207-8
pubmed: 7298864
Neurol Res Pract. 2021 May 4;3(1):23
pubmed: 33941289
Int J Pharm. 2016 Oct 30;512(2):374-381
pubmed: 26970368
Int J Pharm. 2012 Jul 1;430(1-2):197-206
pubmed: 22525080
Dysphagia. 2016 Feb;31(1):24-32
pubmed: 26590572
Case Rep Neurol. 2018 Mar 28;10(1):101-107
pubmed: 29681829
Pharmaceutics. 2020 Aug 08;12(8):
pubmed: 32784378
Dysphagia. 2011 Mar;26(1):92-6
pubmed: 21127909
Dysphagia. 2019 Feb;34(1):119-128
pubmed: 29995244
Mov Disord. 2007 Sep;22 Suppl 17:S379-84
pubmed: 18175400
Neurology. 2016 Sep 27;87(13):1422
pubmed: 27672167
Eur J Neurol. 2021 May;28(5):1765-1770
pubmed: 33338309
J Clin Pharmacol. 1986 Feb;26(2):141-6
pubmed: 3950057
J Pharm Pharmacol. 2014 Jan;66(1):32-9
pubmed: 24128037
Eur J Neurol. 2021 Mar;28(3):754-762
pubmed: 33084118
Nurs Stand. 2002 Jul 3-9;16(42):33-8
pubmed: 12216309
Front Surg. 2019 Jul 24;6:43
pubmed: 31396520
Front Aging Neurosci. 2022 Jul 28;14:912691
pubmed: 35966778
Parkinsonism Relat Disord. 2020 Jun;75:1-6
pubmed: 32417630
Mov Disord. 2015 Oct;30(12):1591-601
pubmed: 26474316
J Pharm Pharm Sci. 2014;17(2):207-19
pubmed: 24934549
Neurogastroenterol Motil. 2019 Nov;31(11):e13690
pubmed: 31381234
Eur J Clin Pharmacol. 2016 Feb;72(2):141-51
pubmed: 26573594
J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4
pubmed: 1564476
Dysphagia. 1996 Spring;11(2):93-8
pubmed: 8721066
J Pharm Pharmacol. 1985 Feb;37(2):126-9
pubmed: 2858546
Dysphagia. 2022 Aug;37(4):909-922
pubmed: 34652512
Br Med J (Clin Res Ed). 1982 Dec 11;285(6356):1717-9
pubmed: 6816343
Curr Ther Res Clin Exp. 2015 Aug 20;77:79-82
pubmed: 26543509
Pharm World Sci. 2001 Oct;23(5):185-8
pubmed: 11721676
Mov Disord Clin Pract. 2020 Feb 27;7(3):273-278
pubmed: 32258224
Ann Pharmacother. 2003 Oct;37(10):1420-3
pubmed: 14519033
Eur J Clin Pharmacol. 2013 Apr;69(4):937-48
pubmed: 23052416
Parkinsonism Relat Disord. 2012 May;18(4):311-5
pubmed: 22137459
Pharmaceutics. 2018 Dec 16;10(4):
pubmed: 30558366
J Am Med Dir Assoc. 2022 Aug;23(8):1360-1366
pubmed: 34678269
Parkinsonism Relat Disord. 2019 May;62:51-56
pubmed: 30770254