Apolipoprotein D facilitate the proliferation of BmNPV.

Animals Apolipoproteins D / metabolism Neurodegenerative Diseases Insect Proteins / metabolism Bombyx / metabolism Cell Proliferation Mammals / metabolism
ApoD BmNPV Bombyx mori

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
31 Dec 2022
Historique:
received: 22 08 2022
revised: 30 10 2022
accepted: 02 11 2022
pubmed: 14 11 2022
medline: 15 12 2022
entrez: 13 11 2022
Statut: ppublish

Résumé

The silkworm, Bombyx mori, a model Lepidopteran specie, is an important economic insect. It is specifically infected by Bombyx mori nucleopolyhedrovirus (BmNPV), causing huge losses to the sericulture industry. Therefore, the understandings of the interaction mechanism between BmNPV and the host will help to provide the theoretical basis for the sericulture industry to control BmNPV. Apolipoprotein D (ApoD) is a member of lipid transport family and capable of binding to a variety of lipophilic ligands. ApoD is mainly used in neurodegenerative disease research in mammals, and there is little research on ApoD against viruses. Here, we explored the effects of Bombyx mori Apolipoprotein D (BmApoD) on BmNPV replication. We knocked out and overexpressed BmApoD in BmN cells and infected them with Bombyx mori nucleopolyhedrovirus (BmNPV). The results showed that BmApoD promote the replication of BmNPV in BmN cells. It was also confirmed that BmApoD promote the replication of BmNPV after knocking down BmApoD in silkworm larvae. This study is the first to explore the role of ApoD in insect-virus interactions, providing new insights into the functional role of ApoD.

Identifiants

DOI: 10.1016/j.ijbiomac.2022.11.032 PMID: 36372108
pubmed: 36372108
pii: S0141-8130(22)02577-6
doi: 10.1016/j.ijbiomac.2022.11.032
pii:
doi:

Substances chimiques

Apolipoproteins D 0
Insect Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

830-836

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no conflicts of financial interest.

Auteurs

Shigang Fei (S)

Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.

Junming Xia (J)

Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.

Guangyu Ma (G)

Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.

Mengmeng Zhang (M)

Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.

Jingchen Sun (J)

Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China. Electronic address: cyfz@scau.edu.cn.

Min Feng (M)

Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China. Electronic address: hunanfengmin@scau.edu.cn.

Yeyuan Wang (Y)

Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China. Electronic address: yyw@scau.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Apolipoprotein D facilitate the proliferation of BmNPV.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines D › Apolipoprotein D facilitate the proliferation of BmNPV.
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Apolipoprotein D facilitate the proliferation of BmNPV.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Apolipoprotein D facilitate the proliferation of BmNPV.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Lepidoptera › Papillons de nuit › Bombyx › Apolipoprotein D facilitate the proliferation of BmNPV.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Apolipoprotein D facilitate the proliferation of BmNPV.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Apolipoprotein D facilitate the proliferation of BmNPV.