Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension.

Animals Rats DNA Methylation Glucosephosphate Dehydrogenase / genetics Hypertension, Pulmonary / genetics Oxygen Cell Hypoxia DNA Modification Methylases / metabolism Gene Expression Regulation, Enzymologic / genetics Disease Models, Animal
DNA Sugen5416 VEGF blocker acetylation epigenetics experimental histone hypoxia methylation methyltransferases normoxia pulmonary arterial hypertension rats

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
12 2022
Historique:
received: 28 01 2022
revised: 30 10 2022
accepted: 31 10 2022
pubmed: 14 11 2022
medline: 6 1 2023
entrez: 13 11 2022
Statut: ppublish

Résumé

DNA methylation potentially contributes to the pathogenesis of pulmonary hypertension (PH). However, the role of DNA methyltransferases (DNMTs: 1, 3a, and 3b), the epigenetic writers, in modulating DNA methylation observed in PH remains elusive. Our objective was to determine DNMT activity and expression in the lungs of experimental rat models of PH. Because the activity of DNMTs is metabolically driven, another objective was to determine the role of glucose-6-phosphate dehydrogenase (G6PD) in regulating DNMT expression and activity in the lungs of novel loss-of-function Mediterranean G6PD variant (G6PD

Identifiants

DOI: 10.1016/j.jbc.2022.102691 PMID: 36372233 PMC: PMC9731845
pubmed: 36372233
pii: S0021-9258(22)01134-6
doi: 10.1016/j.jbc.2022.102691
pmc: PMC9731845
pii:
doi:

Substances chimiques

Glucosephosphate Dehydrogenase EC 1.1.1.49
Oxygen S88TT14065
DNA Modification Methylases EC 2.1.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102691

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL146442
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL161004
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL166546
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132574
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148151
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL150032
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149714
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.

Auteurs

Christina Jacob (C)

Department of Pharmacology, New York Medical College, Valhalla, New York, USA.

Atsushi Kitagawa (A)

Department of Pharmacology, New York Medical College, Valhalla, New York, USA.

Christina Signoretti (C)

Department of Pharmacology, New York Medical College, Valhalla, New York, USA.

Monika Dzieciatkowska (M)

Department of Biochemistry & Molecular Genetics, School of Medicine, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.

Angelo D'Alessandro (A)

Department of Biochemistry & Molecular Genetics, School of Medicine, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.

Aaditya Gupte (A)

Department of Pharmacology, New York Medical College, Valhalla, New York, USA.

Shakib Hossain (S)

Department of Pharmacology, New York Medical College, Valhalla, New York, USA.

Catherine A D'Addario (CA)

Department of Pharmacology, New York Medical College, Valhalla, New York, USA.

Rakhee Gupte (R)

Department of Pharmacology, New York Medical College, Valhalla, New York, USA.

Sachin A Gupte (SA)

Department of Pharmacology, New York Medical College, Valhalla, New York, USA. Electronic address: s_gupte@nymc.edu.

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Classifications MeSH

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questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Mediterranean G6PD variant mitigates...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › Carbohydrate dehydrogenases › Glucose 6-phosphate dehydrogenase › Mediterranean G6PD variant mitigates...
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