Intermediate monocytes expansion and homing markers expression in COVID-19 patients associate with kidney dysfunction.

Humans Monocytes COVID-19 / metabolism Receptors, CCR2 / metabolism SARS-CoV-2 Kidney
Covid-19 C–C motif chemokine receptor 2 Innate immunity Monocytes SARS-CoV-2

Journal

Clinical and experimental medicine
ISSN: 1591-9528
Titre abrégé: Clin Exp Med
Pays: Italy
ID NLM: 100973405

Informations de publication

Date de publication:
Aug 2023
Historique:
received: 25 05 2022
accepted: 14 10 2022
medline: 1 8 2023
pubmed: 15 11 2022
entrez: 14 11 2022
Statut: ppublish

Résumé

Patients with severe SARS-CoV-2 infection have an overwhelming inflammatory response characterized by remarkable organs monocyte infiltration. We performed an immunophenotypic analysis on circulating monocytes in 19 COVID-19 patients in comparison with 11 naïve HIV-1 patients and 10 healthy subjects. Reduced frequency of classical monocytes and increased frequency of intermediate monocytes characterized COVID-19 patients with respect to both HIV naïve patients and healthy subjects. Intensity of C-C motif chemokine receptor 2 (CCR2) monocyte expression highly correlated with parameters of kidney dysfunction. Our data indicate that highly activated monocytes of COVID-19 patients may be pathogenically associated with the development of renal disease.

Identifiants

DOI: 10.1007/s10238-022-00927-9 PMID: 36372857 PMC: PMC9660192
pubmed: 36372857
doi: 10.1007/s10238-022-00927-9
pii: 10.1007/s10238-022-00927-9
pmc: PMC9660192
doi:

Substances chimiques

Receptors, CCR2 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1235-1242

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

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Auteurs

Chiara Dentone (C)

Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy. chiaradentone@libero.it.
ORCID: 0000-0002-9096-5812

Daniela Fenoglio (D)

Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.

Alessia Parodi (A)

Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Tiziana Altosole (T)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.

Antonio Di Biagio (A)

Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy.
Department of Health Sciences, University of Genoa, 16132, Genoa, Italy.

Federica Bozzano (F)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.

Giorgia Nasi (G)

Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Antonio Vena (A)

Department of Health Sciences, University of Genoa, 16132, Genoa, Italy.

Marina Fabbi (M)

Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Francesca Ferrera (F)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.

Bianca Bruzzone (B)

Hygiene Unit, IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.

Mauro Giacomini (M)

Department of Informatics Bioengineering, Robotics, and Systems Engineering (DIBRIS), University of Genoa, 16145, Genoa, Italy.

Daniele Roberto Giacobbe (DR)

Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy.
Department of Health Sciences, University of Genoa, 16132, Genoa, Italy.

Paolo Pelosi (P)

Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132, Genoa, Italy.
Anesthesia and Intensive Care Unit, IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.

Andrea De Maria (A)

Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy.
Department of Health Sciences, University of Genoa, 16132, Genoa, Italy.

Matteo Bassetti (M)

Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy.
Department of Health Sciences, University of Genoa, 16132, Genoa, Italy.

Raffaele De Palma (R)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.
Internal Medicine, Clinical Immunology and Translational Medicine Unit, IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.

Gilberto Filaci (G)

Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Intermediate monocytes expansion and homing...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Intermediate monocytes expansion and homing...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Intermediate monocytes expansion and homing...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › Récepteurs CCR › Récepteurs CCR2 › Intermediate monocytes expansion and homing...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Intermediate monocytes expansion and homing...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Intermediate monocytes expansion and homing...