Hematopoietic-specific melanocortin 1 receptor signaling protects against nephrotoxic serum nephritis and mediates the beneficial effect of melanocortin therapy.

Animals Mice Rabbits Receptor, Melanocortin, Type 1 / genetics Nephritis Renal Insufficiency Kidney Signal Transduction NF-kappa B
ACTH crescentic glomerulonephritis immune response inflammation lymphocytes macrophage

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
Feb 2023
Historique:
received: 05 08 2021
revised: 25 08 2022
accepted: 01 09 2022
pmc-release: 01 02 2024
pubmed: 15 11 2022
medline: 25 1 2023
entrez: 14 11 2022
Statut: ppublish

Résumé

The melanocortin hormone system has emerged as a novel therapeutic target for treating refractory glomerular diseases. However, the role of hematopoietic melanocortin 1 receptor (MC1R) signaling remains unknown. Upon insult by rabbit nephrotoxic serum, MC1R null-mutant mice developed more severe crescentic glomerulonephritis than wild-type mice, marked by aggravated proteinuria, kidney dysfunction and histologic lesions. Melanocortin therapy, using Repository Corticotropin Injection (Acthar Gel), the pan-melanocortin receptor agonist NDP-MSH, or the MC1R agonist MS05, ameliorated experimental nephritis in wild-type mice but this effect was blunted in null mice. Exacerbated experimental nephritis in null mice was associated with increased glomerular deposition of autologous IgG and C5b-9, in parallel with higher circulating levels of autologous IgG2c and IgG3. Additionally, the Th1 immune response was potentiated in null mice with experimental nephritis, accompanied by diminished kidney FoxP3

Identifiants

DOI: 10.1016/j.kint.2022.09.025 PMID: 36374665 PMC: PMC10431720
pubmed: 36374665
pii: S0085-2538(22)00905-X
doi: 10.1016/j.kint.2022.09.025
pmc: PMC10431720
mid: NIHMS1851794
pii:
doi:

Substances chimiques

Receptor, Melanocortin, Type 1 0
NF-kappa B 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

331-342

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK114006
Pays : United States

Informations de copyright

Copyright © 2022 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

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Auteurs

Xuejing Guan (X)

Division of Nephrology, Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA; The Center for Diabetes and Endocrine Research, University of Toledo Medical Center, Toledo, Ohio, USA.

Bohan Chen (B)

Division of Nephrology, Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA; The Center for Diabetes and Endocrine Research, University of Toledo Medical Center, Toledo, Ohio, USA; Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, USA.

Deepak K Malhotra (DK)

Division of Nephrology, Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA.

Amira F Gohara (AF)

Department of Pathology, University of Toledo Medical Center, Toledo, Ohio, USA.

Lance D Dworkin (LD)

Division of Nephrology, Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA.

Rujun Gong (R)

Division of Nephrology, Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA; The Center for Diabetes and Endocrine Research, University of Toledo Medical Center, Toledo, Ohio, USA; Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, Ohio, USA. Electronic address: Rujun.Gong@UToledo.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hematopoietic-specific melanocortin 1 receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hematopoietic-specific melanocortin 1 receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › Hematopoietic-specific melanocortin 1 receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur corticotrophine › Récepteurs à la mélanocortine › Récepteur de la mélanocortine de type 1 › Hematopoietic-specific melanocortin 1 receptor...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Néphrite › Hematopoietic-specific melanocortin 1 receptor...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Hematopoietic-specific melanocortin 1 receptor...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Hematopoietic-specific melanocortin 1 receptor...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Hematopoietic-specific melanocortin 1 receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Hematopoietic-specific melanocortin 1 receptor...