Blood brain barrier and inflammation in depression.
Blood brain barrier
Depression
Inflammation
Stress
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
04
05
2022
revised:
26
10
2022
accepted:
09
11
2022
pubmed:
15
11
2022
medline:
17
12
2022
entrez:
14
11
2022
Statut:
ppublish
Résumé
The blood brain barrier (BBB) is a vital structure to protect the brain, tightly filtering the passage of nutrients and molecules from the blood to the brain. This is critical for maintaining the proper functioning of the brain, and any disruption in the BBB has detrimental consequences often leading to diseases. It is not clear whether disruption of the BBB occurs first in depression or is the consequence of the disease, however disruption of the BBB has been observed in depressed patients and evidence points to the role of important culprits in depression, stress and inflammation in disrupting the integrity of the BBB. The mechanisms whereby stress, and inflammation affect the BBB remain to be fully understood. Yet, the role of cytokines in regulating tight junction protein expression seems crucial. Altogether, the findings in depression suggest that acting at the BBB level might provide therapeutic benefit in depression.
Identifiants
pubmed: 36375722
pii: S0969-9961(22)00318-7
doi: 10.1016/j.nbd.2022.105926
pmc: PMC10035601
mid: NIHMS1876908
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
105926Subventions
Organisme : NIMH NIH HHS
ID : R01 MH104656
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110415
Pays : United States
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest.
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