H7N9 avian influenza virus infection in men is associated with testosterone depletion.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
14 11 2022
14 11 2022
Historique:
received:
02
06
2020
accepted:
27
10
2022
entrez:
14
11
2022
pubmed:
15
11
2022
medline:
18
11
2022
Statut:
epublish
Résumé
Human infections with H7N9 avian influenza A virus that emerged in East China in 2013 and caused high morbidity rates were more frequently detected in men than in women over the last five epidemic waves. However, molecular markers associated with poor disease outcomes in men are still unknown. In this study, we systematically analysed sex hormone and cytokine levels in males and females with laboratory-confirmed H7N9 influenza in comparison to H7N9-negative control groups as well as laboratory-confirmed seasonal H1N1/H3N2 influenza cases (n = 369). Multivariable analyses reveal that H7N9-infected men present with considerably reduced testosterone levels associated with a poor outcome compared to non-infected controls. Regression analyses reveal that testosterone levels in H7N9-infected men are negatively associated with the levels of several pro-inflammatory cytokines, such as IL-6 and IL-15. To assess whether there is a causal relationship between low testosterone levels and avian H7N9 influenza infection, we used a mouse model. In male mice, we show that respiratory H7N9 infection leads to a high viral load and inflammatory cytokine response in the testes as well as a reduction in pre-infection plasma testosterone levels. Collectively, these findings suggest that monitoring sex hormone levels may support individualized management for patients with avian influenza infections.
Identifiants
pubmed: 36376288
doi: 10.1038/s41467-022-34500-5
pii: 10.1038/s41467-022-34500-5
pmc: PMC9662777
doi:
Substances chimiques
Testosterone
3XMK78S47O
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6936Informations de copyright
© 2022. The Author(s).
Références
Nat Rev Immunol. 2010 Mar;10(3):170-81
pubmed: 20154735
J Clin Endocrinol Metab. 2006 Jan;91(1):345-7
pubmed: 16263825
J Infect Dis. 2013 Dec 15;208(12):1962-7
pubmed: 23990573
Nature. 2013 Jul 25;499(7459):500-3
pubmed: 23823727
PLoS One. 2012;7(5):e37539
pubmed: 22624047
Biochem Biophys Res Commun. 2016 Sep 2;477(4):895-901
pubmed: 27392713
J Interferon Cytokine Res. 1999 Nov;19(11):1271-6
pubmed: 10574620
Cytokine Growth Factor Rev. 2020 Aug;54:24-31
pubmed: 32536564
Front Immunol. 2020 Apr 22;11:697
pubmed: 32431696
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
J Immunol. 2009 Mar 1;182(5):3063-71
pubmed: 19234203
Andrologia. 2003 Feb;35(1):55-63
pubmed: 12558529
N Engl J Med. 2013 May 16;368(20):1888-97
pubmed: 23577628
Crit Care. 2010;14(6):R203
pubmed: 21062445
Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1234-L1244
pubmed: 27815260
Lancet Infect Dis. 2017 Aug;17(8):822-832
pubmed: 28583578
J Clin Endocrinol Metab. 2016 Feb;101(2):539-49
pubmed: 26600270
Western Pac Surveill Response J. 2013 Apr 20;4(2):1-3
pubmed: 24015363
Clin Chem Lab Med. 2018 Jun 27;56(7):1152-1160
pubmed: 29729137
Nat Rev Cancer. 2014 Mar;14(3):187-98
pubmed: 24561445
J Clin Med. 2018 Dec 14;7(12):
pubmed: 30558178
Am J Reprod Immunol. 2004 Oct;52(4):237-43
pubmed: 15494044
PLoS Curr. 2013 May 15;5:
pubmed: 23873126
J Infect Dis. 2014 Jul 15;209 Suppl 3:S93-9
pubmed: 24966196
Int J Cancer. 2003 May 20;105(1):92-7
pubmed: 12672036
Front Immunol. 2020 Mar 13;11:450
pubmed: 32231671
Nat Rev Immunol. 2016 Oct;16(10):626-38
pubmed: 27546235
N Engl J Med. 2014 Feb 6;370(6):520-32
pubmed: 23614499
Hum Reprod Update. 2018 Jul 1;24(4):416-441
pubmed: 29648649
Nat Commun. 2020 Dec 9;11(1):6317
pubmed: 33298944
Endocr Connect. 2018 Jan;7(1):220-231
pubmed: 29233816
Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5676-81
pubmed: 24706798
PLoS Pathog. 2011 Jul;7(7):e1002149
pubmed: 21829352
Cancer Epidemiol Biomarkers Prev. 2002 Oct;11(10 Pt 1):1041-7
pubmed: 12376505
Front Immunol. 2018 Jun 04;9:1269
pubmed: 29915601