Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
15 11 2022
15 11 2022
Historique:
received:
12
10
2022
accepted:
02
11
2022
revised:
27
10
2022
entrez:
15
11
2022
pubmed:
16
11
2022
medline:
19
11
2022
Statut:
epublish
Résumé
Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment. Its etiology is largely unknown, but twin studies suggest that it is moderately heritable. In this study, we pooled phenotypic and genomic data from seven international cohorts (N = 27,537 individuals) and conducted a genome wide association study (GWAS) meta-analysis of parent- or self-reported hoarding symptoms (HS). We followed up the results with gene-based and gene-set analyses, as well as leave-one-out HS polygenic risk score (PRS) analyses. To examine a possible genetic association between hoarding symptoms and other phenotypes we conducted cross-trait PRS analyses. Though we did not report any genome-wide significant SNPs, we report heritability estimates for the twin-cohorts between 26-48%, and a SNP-heritability of 11% for an unrelated sub-cohort. Cross-trait PRS analyses showed that the genetic risk for schizophrenia and autism spectrum disorder were significantly associated with hoarding symptoms. We also found suggestive evidence for an association with educational attainment. There were no significant associations with other phenotypes previously linked to HD, such as obsessive-compulsive disorder, depression, anxiety, or attention-deficit hyperactivity disorder. To conclude, we found that HS are heritable, confirming and extending previous twin studies but we had limited power to detect any genome-wide significant loci. Much larger samples will be needed to further extend these findings and reach a "gene discovery zone". To move the field forward, future research should not only include genetic analyses of quantitative hoarding traits in larger samples, but also in samples of individuals meeting strict diagnostic criteria for HD, and more ethnically diverse samples.
Identifiants
pubmed: 36379924
doi: 10.1038/s41398-022-02248-7
pii: 10.1038/s41398-022-02248-7
pmc: PMC9666541
doi:
Types de publication
Meta-Analysis
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
479Subventions
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH110427
Pays : United States
Organisme : Versus Arthritis
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U24 MH068457
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R01 HD042157
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089951
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
Références
J Abnorm Psychol. 2011 Aug;120(3):700-7
pubmed: 21668081
Behav Res Ther. 2008 Mar;46(3):334-44
pubmed: 18275935
Br J Psychiatry. 2013 Dec;203(6):445-52
pubmed: 24158881
Nat Genet. 2019 Sep;51(9):1339-1348
pubmed: 31427789
Am J Psychiatry. 2007 Mar;164(3):493-9
pubmed: 17329475
Transl Psychiatry. 2020 May 18;10(1):151
pubmed: 32424139
J Affect Disord. 2019 Sep 1;256:309-316
pubmed: 31200169
Depress Anxiety. 2020 Aug;37(8):760-770
pubmed: 32092211
Twin Res. 2002 Oct;5(5):401-6
pubmed: 12537867
Am J Hum Genet. 2011 Mar 11;88(3):294-305
pubmed: 21376301
Nat Genet. 2014 Nov;46(11):1173-86
pubmed: 25282103
Transl Psychiatry. 2018 Sep 18;8(1):191
pubmed: 30228290
Stat Med. 2002 Jun 15;21(11):1539-58
pubmed: 12111919
Am J Psychiatry. 2008 Oct;165(10):1289-98
pubmed: 18483134
PLoS Comput Biol. 2015 Apr 17;11(4):e1004219
pubmed: 25885710
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Depress Anxiety. 2011 Oct 3;28(10):876-84
pubmed: 21770000
J Anxiety Disord. 2006;20(5):675-86
pubmed: 16112837
Gigascience. 2019 Jul 1;8(7):
pubmed: 31307061
Nat Genet. 2019 Mar;51(3):431-444
pubmed: 30804558
Am J Med Genet B Neuropsychiatr Genet. 2011 Mar;156(2):240-2
pubmed: 21302353
Cell. 2019 Dec 12;179(7):1469-1482.e11
pubmed: 31835028
Behav Res Ther. 1993 May;31(4):367-81
pubmed: 8512538
Twin Res Hum Genet. 2013 Apr;16(2):560-74
pubmed: 23527680
Arch Gen Psychiatry. 2011 Jun;68(6):637-44
pubmed: 21646580
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
Bioinformatics. 2020 Feb 1;36(3):930-933
pubmed: 31393554
Biometrika. 1950 Dec;37(3-4):256-66
pubmed: 14801052
Twin Res Hum Genet. 2019 Dec;22(6):672-680
pubmed: 31747977
Nat Genet. 2018 Jul;50(7):920-927
pubmed: 29942085
Nature. 2022 Apr;604(7906):502-508
pubmed: 35396580
Nat Genet. 2019 Jan;51(1):63-75
pubmed: 30478444
Mol Psychiatry. 2018 May;23(5):1181-1188
pubmed: 28761083
PLoS One. 2017 Jun 28;12(6):e0179541
pubmed: 28658283
Health Soc Care Community. 2000 Jul;8(4):229-234
pubmed: 11560692
J Am Acad Child Adolesc Psychiatry. 2016 Apr;55(4):310-318.e4
pubmed: 27015722
J Abnorm Child Psychol. 2013 Apr;41(3):497-507
pubmed: 23315233
Am J Hum Genet. 2011 Jan 7;88(1):76-82
pubmed: 21167468
J Abnorm Psychol. 2010 Nov;119(4):672-82
pubmed: 21090873
PLoS One. 2013 Jul 10;8(7):e69140
pubmed: 23874893
Arch Gen Psychiatry. 2009 Apr;66(4):408-16
pubmed: 19349310
Nat Commun. 2017 Nov 28;8(1):1826
pubmed: 29184056
Twin Res Hum Genet. 2011 Dec;14(6):495-508
pubmed: 22506305
Am J Hum Genet. 2002 Apr;70(4):896-904
pubmed: 11840360
Nat Genet. 2017 Jun;49(6):834-841
pubmed: 28436984
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
Nature. 2018 Oct;562(7726):203-209
pubmed: 30305743
Nat Neurosci. 2019 Mar;22(3):343-352
pubmed: 30718901
Nat Genet. 2018 Aug;50(8):1112-1121
pubmed: 30038396
Bioinformatics. 2017 Jan 15;33(2):272-279
pubmed: 27663502
Am J Geriatr Psychiatry. 2017 Mar;25(3):245-255
pubmed: 27939851
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Int J Geriatr Psychiatry. 2010 Feb;25(2):142-9
pubmed: 19548272
Depress Anxiety. 2015 Oct;32(10):728-36
pubmed: 26130515
Am J Med Genet B Neuropsychiatr Genet. 2014 Jun;165B(4):314-25
pubmed: 24756981
Genes Brain Behav. 2008 Oct;7(7):778-85
pubmed: 18616610
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379
Depress Anxiety. 2013 Aug;30(8):741-8
pubmed: 23606213
Psychol Assess. 2013 Mar;25(1):194-203
pubmed: 22984803
J Clin Psychiatry. 2005 Sep;66(9):1155-60
pubmed: 16187774
J Am Acad Child Adolesc Psychiatry. 2016 Oct;55(10):896-905.e6
pubmed: 27663945
Psychol Med. 2014 Oct;44(13):2867-76
pubmed: 25066062
Behav Res Ther. 2011 Feb;49(2):120-5
pubmed: 21193171
Psychiatry Res. 2016 Mar 30;237:331-8
pubmed: 26805562
Genomics. 1996 Sep 1;36(2):354-8
pubmed: 8812465
Behav Res Ther. 2005 Feb;43(2):269-76
pubmed: 15629755
Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):1000-2
pubmed: 18286588
Nat Genet. 2019 Dec;51(12):1749-1755
pubmed: 31768069
Twin Res Hum Genet. 2013 Feb;16(1):317-29
pubmed: 23137839
Behav Res Ther. 2002 May;40(5):517-28
pubmed: 12043707
Psychiatry Res. 2010 Jun 30;178(1):147-52
pubmed: 20452042
Am J Psychiatry. 2009 Oct;166(10):1156-61
pubmed: 19687130
Transl Psychiatry. 2021 Feb 2;11(1):91
pubmed: 33531474
Eur Child Adolesc Psychiatry. 2021 Mar;30(3):415-425
pubmed: 32306089
Am J Psychiatry. 2016 Dec 1;173(12):1213-1222
pubmed: 27363509
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120