Quantitative measurement of cartilage morphology in osteoarthritis: current knowledge and future directions.
Cartilage loss
Knee
MRI
Osteoarthritis
Journal
Skeletal radiology
ISSN: 1432-2161
Titre abrégé: Skeletal Radiol
Pays: Germany
ID NLM: 7701953
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
29
08
2022
accepted:
31
10
2022
revised:
29
10
2022
medline:
20
9
2023
pubmed:
16
11
2022
entrez:
15
11
2022
Statut:
ppublish
Résumé
Quantitative measures of cartilage morphology ("cartilage morphometry") extracted from high resolution 3D magnetic resonance imaging (MRI) sequences have been shown to be sensitive to osteoarthritis (OA)-related change and also to treatment interventions. Cartilage morphometry is therefore nowadays widely used as outcome measure for observational studies and randomized interventional clinical trials. The objective of this narrative review is to summarize the current status of cartilage morphometry in OA research, to provide insights into aspects relevant for the design of future studies and clinical trials, and to give an outlook on future developments. It covers the aspects related to the acquisition of MRIs suitable for cartilage morphometry, the analysis techniques needed for deriving quantitative measures from the MRIs, the quality assurance required for providing reliable cartilage measures, and the appropriate participant recruitment criteria for the enrichment of study cohorts with knees likely to show structural progression. Finally, it provides an overview over recent clinical trials that relied on cartilage morphometry as a structural outcome measure for evaluating the efficacy of disease-modifying OA drugs (DMOAD).
Identifiants
pubmed: 36380243
doi: 10.1007/s00256-022-04228-w
pii: 10.1007/s00256-022-04228-w
pmc: PMC10509082
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2107-2122Informations de copyright
© 2022. The Author(s).
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