Impact of upper and lower respiratory symptoms on COVID-19 outcomes: a multicenter retrospective cohort study.
COVID-19
Lower respiratory tract symptoms
Primary care
SARS-CoV-2 infection
Upper respiratory tract symptoms
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
15 Nov 2022
15 Nov 2022
Historique:
received:
27
07
2022
accepted:
12
10
2022
entrez:
15
11
2022
pubmed:
16
11
2022
medline:
19
11
2022
Statut:
epublish
Résumé
Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory symptoms on COVID-19 outcomes in the same population have not been compared. The objective of this study was to characterize upper and lower respiratory symptoms and compare their impacts on outcomes of hospitalized COVID-19 patients. This was a multicenter, retrospective cohort study; the database from the Japan COVID-19 Task Force was used. A total of 3314 COVID-19 patients were included in the study, and the data on respiratory symptoms were collected. The participants were classified according to their respiratory symptoms (Group 1: no respiratory symptoms, Group 2: only upper respiratory symptoms, Group 3: only lower respiratory symptoms, and Group 4: both upper and lower respiratory symptoms). The impacts of upper and lower respiratory symptoms on the clinical outcomes were compared. The primary outcome was the percentage of patients with poor clinical outcomes, including the need for oxygen supplementation via high-flow oxygen therapy, mechanical ventilation, and extracorporeal membrane oxygenation or death. Of the 3314 COVID-19 patients, 605, 1331, 1229, and 1149 were classified as Group 1, Group 2, Group 3, and Group 4, respectively. In univariate analysis, patients in Group 2 had the best clinical outcomes among all groups (odds ratio [OR]: 0.21, 95% confidence interval [CI]: 0.11-0.39), while patients in Group 3 had the worst outcomes (OR: 3.27, 95% CI: 2.43-4.40). Group 3 patients had the highest incidence of pneumonia, other complications due to secondary infections, and thrombosis during the clinical course. Upper and lower respiratory tract symptoms had vastly different impacts on the clinical outcomes of COVID-19.
Sections du résumé
BACKGROUND
BACKGROUND
Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory symptoms on COVID-19 outcomes in the same population have not been compared. The objective of this study was to characterize upper and lower respiratory symptoms and compare their impacts on outcomes of hospitalized COVID-19 patients.
METHODS
METHODS
This was a multicenter, retrospective cohort study; the database from the Japan COVID-19 Task Force was used. A total of 3314 COVID-19 patients were included in the study, and the data on respiratory symptoms were collected. The participants were classified according to their respiratory symptoms (Group 1: no respiratory symptoms, Group 2: only upper respiratory symptoms, Group 3: only lower respiratory symptoms, and Group 4: both upper and lower respiratory symptoms). The impacts of upper and lower respiratory symptoms on the clinical outcomes were compared. The primary outcome was the percentage of patients with poor clinical outcomes, including the need for oxygen supplementation via high-flow oxygen therapy, mechanical ventilation, and extracorporeal membrane oxygenation or death.
RESULTS
RESULTS
Of the 3314 COVID-19 patients, 605, 1331, 1229, and 1149 were classified as Group 1, Group 2, Group 3, and Group 4, respectively. In univariate analysis, patients in Group 2 had the best clinical outcomes among all groups (odds ratio [OR]: 0.21, 95% confidence interval [CI]: 0.11-0.39), while patients in Group 3 had the worst outcomes (OR: 3.27, 95% CI: 2.43-4.40). Group 3 patients had the highest incidence of pneumonia, other complications due to secondary infections, and thrombosis during the clinical course.
CONCLUSIONS
CONCLUSIONS
Upper and lower respiratory tract symptoms had vastly different impacts on the clinical outcomes of COVID-19.
Identifiants
pubmed: 36380316
doi: 10.1186/s12931-022-02222-3
pii: 10.1186/s12931-022-02222-3
pmc: PMC9665023
doi:
Types de publication
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
315Subventions
Organisme : Precursory Research for Embryonic Science and Technology
ID : JPMJPR21R7
Organisme : Japan Agency for Medical Research and Development
ID : JP21wm0325031
Organisme : Japan Agency for Medical Research and Development
ID : JP21km0405211
Organisme : Japan Agency for Medical Research and Development
ID : JP20nk0101612
Organisme : Japan Agency for Medical Research and Development
ID : JP20fk0108415
Organisme : Core Research for Evolutional Science and Technology
ID : JPMJCR20H2
Informations de copyright
© 2022. The Author(s).
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