Human neutrophils
human infection
human neutrophiis
murine models
murine neutrophils
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
pmc-release:
01
03
2024
medline:
29
3
2023
pubmed:
17
11
2022
entrez:
16
11
2022
Statut:
ppublish
Résumé
Human and murine neutrophils differ with respect to representation in blood, receptors, nuclear morphology, signaling pathways, granule proteins, NADPH oxidase regulation, magnitude of oxidant and hypochlorous acid production, and their repertoire of secreted molecules. These differences often matter and can undermine extrapolations from murine studies to clinical care, as illustrated by several failed therapeutic interventions based on mouse models. Likewise, coevolution of host and pathogen undercuts fidelity of murine models of neutrophil-predominant human infections. However, murine systems that accurately model the human condition can yield insights into human biology difficult to obtain otherwise. The challenge for investigators who employ murine systems is to distinguish models from pretenders and to know when the mouse provides biologically accurate insights. Testing with human neutrophils observations made in murine systems would provide a safeguard but is not always possible. At a minimum, studies that use exclusively murine neutrophils should have accurate titles supported by data and restrict conclusions to murine neutrophils and not encompass all neutrophils. For now, the integration of evidence from studies of neutrophil biology performed using valid murine models coupled with testing in vitro of human neutrophils combines the best of both approaches to elucidate the mysteries of human neutrophil biology.
Identifiants
pubmed: 36380497
doi: 10.1111/imr.13154
pmc: PMC10049967
mid: NIHMS1843669
doi:
Substances chimiques
NADPH Oxidases
EC 1.6.3.-
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
442-456Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES005605
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132335
Pays : United States
Informations de copyright
© 2022 The Author. Immunological Reviews published by John Wiley & Sons Ltd.
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