Infectious consequences of the AKI-to-CKD transition.
acute kidney injury
chronic kidney disease
infections
outcomes
persistent kidney damage
Journal
Clinical kidney journal
ISSN: 2048-8505
Titre abrégé: Clin Kidney J
Pays: England
ID NLM: 101579321
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
06
03
2022
entrez:
16
11
2022
pubmed:
17
11
2022
medline:
17
11
2022
Statut:
epublish
Résumé
Acute kidney injury (AKI) is associated with short- and long-term complications but the consequences of the AKI-to-CKD transition are still poorly understood. We aimed to evaluate the association between the AKI-to-CKD transition and the long-term risk of infection. This retrospective study included patients admitted in a tertiary hospital with community-acquired AKI in 2013 and 2014 who had their estimated glomerular filtration rate (eGFR) assessed at 3 months (±2 weeks) after serum creatinine peaked in the AKI episode. Key exclusion criteria were baseline CKD or confounding factors (active neoplasia, primary immunodeficiency, human immunodeficiency virus, immunosuppressive drugs). The association between the AKI-to-CKD transition (defined as an eGFR <60 ml/min/1.73 m Among the 1731 patients admitted with AKI, 367 (21%) were included in the present analysis (64% male, 71 ± 15 years). Three months after AKI, 159 (43%) developed AKI-to-CKD transition. Baseline and post-AKI eGFR were independent predictors of AKI-to-CKD transition [hazard ratio (HR) 0.97, The AKI-to-CKD transition independently predicts the long-term risk of infection following an episode of AKI.
Sections du résumé
Background
UNASSIGNED
Acute kidney injury (AKI) is associated with short- and long-term complications but the consequences of the AKI-to-CKD transition are still poorly understood. We aimed to evaluate the association between the AKI-to-CKD transition and the long-term risk of infection.
Methods
UNASSIGNED
This retrospective study included patients admitted in a tertiary hospital with community-acquired AKI in 2013 and 2014 who had their estimated glomerular filtration rate (eGFR) assessed at 3 months (±2 weeks) after serum creatinine peaked in the AKI episode. Key exclusion criteria were baseline CKD or confounding factors (active neoplasia, primary immunodeficiency, human immunodeficiency virus, immunosuppressive drugs). The association between the AKI-to-CKD transition (defined as an eGFR <60 ml/min/1.73 m
Results
UNASSIGNED
Among the 1731 patients admitted with AKI, 367 (21%) were included in the present analysis (64% male, 71 ± 15 years). Three months after AKI, 159 (43%) developed AKI-to-CKD transition. Baseline and post-AKI eGFR were independent predictors of AKI-to-CKD transition [hazard ratio (HR) 0.97,
Conclusions
UNASSIGNED
The AKI-to-CKD transition independently predicts the long-term risk of infection following an episode of AKI.
Identifiants
pubmed: 36381366
doi: 10.1093/ckj/sfac178
pii: sfac178
pmc: PMC9664570
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2237-2244Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA.
Références
Am J Kidney Dis. 2014 May;63(5):713-35
pubmed: 24647050
Kidney Int. 2017 Aug;92(2):440-452
pubmed: 28416224
Int J Mol Sci. 2022 Feb 01;23(3):
pubmed: 35163625
Am J Kidney Dis. 2021 Nov;78(5):736-749
pubmed: 34518032
Intern Med J. 2022 May;52(5):834-840
pubmed: 33342021
Kidney Int. 2022 Jan;101(1):13-15
pubmed: 34991802
Nat Rev Dis Primers. 2021 Jul 15;7(1):52
pubmed: 34267223
Adv Chronic Kidney Dis. 2019 Jan;26(1):8-15
pubmed: 30876622
An Sist Sanit Navar. 2021 Aug 20;44(2):215-223
pubmed: 34142992
J Am Soc Nephrol. 2022 Feb;33(2):259-278
pubmed: 34907031
Am J Cardiol. 2015 Jul 1;116(1):104-11
pubmed: 25943992
JAMA. 2014 Feb 5;311(5):507-20
pubmed: 24352797
Diabetes Care. 2017 Jul;40(7):985
pubmed: 28522558
Lancet. 2013 Jul 13;382(9887):170-9
pubmed: 23727171
Nat Rev Nephrol. 2015 Feb;11(2):88-101
pubmed: 25331787
Contrib Nephrol. 2018;193:45-54
pubmed: 29393158
Kidney Int. 2000 Oct;58(4):1758-64
pubmed: 11012910
J Nephrol. 2019 Dec;32(6):967-975
pubmed: 31617159
Clin J Am Soc Nephrol. 2017 Sep 7;12(9):1399-1408
pubmed: 28818849
Nephron. 2020;144(10):498-505
pubmed: 32818930
Nephrol Dial Transplant. 2020 Nov 1;35(11):1894-1900
pubmed: 31219575
Nat Rev Nephrol. 2020 Apr;16(4):193-205
pubmed: 32051567
Am J Kidney Dis. 2013 Jan;61(1):57-66
pubmed: 22889713
Blood Purif. 2016;41(1-3):144-50
pubmed: 26764483