Recognition motifs for importin 4 [(L)PPRS(G/P)P] and importin 5 [KP(K/Y)LV] binding, identified by bio-informatic simulation and experimental
IPO4, Importin 4
IPO5, Importin 5
IPO7, Importin 7
IPOα, Importin α
IPOβ, Importin β
Importin 4
Importin 5
Karyopherins
Nuclear localization signal (NLS)
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
06
2022
revised:
10
10
2022
accepted:
11
10
2022
entrez:
16
11
2022
pubmed:
17
11
2022
medline:
17
11
2022
Statut:
epublish
Résumé
Nuclear translocation of large proteins is mediated through karyopherins, carrier proteins recognizing specific motifs of cargo proteins, known as nuclear localization signals (NLS). However, only few NLS signals have been reported until now. In the present work, NLS signals for Importins 4 and 5 were identified through an unsupervised
Identifiants
pubmed: 36382187
doi: 10.1016/j.csbj.2022.10.015
pii: S2001-0370(22)00462-7
pmc: PMC9646746
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5952-5961Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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