Morphine upregulates Toll-like receptor 4 expression and promotes melanomas in mice.
Morphine
Toll-like receptor 4
melanoma
pain
progression
Journal
Immunopharmacology and immunotoxicology
ISSN: 1532-2513
Titre abrégé: Immunopharmacol Immunotoxicol
Pays: England
ID NLM: 8800150
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
medline:
30
5
2023
pubmed:
17
11
2022
entrez:
16
11
2022
Statut:
ppublish
Résumé
Morphine and other opioids are used to manage cancer-related pain; however, the role of these drugs in cancer progression remains controversial. Emerging evidence indicates that morphine can activate Toll-like receptor 4 (TLR4) and its signaling pathways, by the way the activation and expression of TLR4 can promote melanoma. In this study, we investigated the effects of morphine on the expression of TLR4 and promotion of melanoma in mice. Mice melanoma cells (B16F10) were cultured with morphine (0.1, 1 and 10 µM) for 24 h. In the other experiment, cells were treated with morphine with or without TLR4 agonist (LPS) or antagonist (TAK-242). In Chronic, acute, and escalating doses of morphine increased tumor. Morphine increased the expression of Morphine increases the progression of melanoma cancer and may be related to the increased expression of TLR4. Our results suggest that morphine should be used with caution in patients with melanoma.HighlightsMorphine increases the expression of TLR4 in melanoma.Morphine increases melanoma progression.These effects are mostly observed with chronic and escalating morphine administration.
Sections du résumé
BACKGROUND
UNASSIGNED
Morphine and other opioids are used to manage cancer-related pain; however, the role of these drugs in cancer progression remains controversial. Emerging evidence indicates that morphine can activate Toll-like receptor 4 (TLR4) and its signaling pathways, by the way the activation and expression of TLR4 can promote melanoma. In this study, we investigated the effects of morphine on the expression of TLR4 and promotion of melanoma in mice.
METHODS
UNASSIGNED
Mice melanoma cells (B16F10) were cultured with morphine (0.1, 1 and 10 µM) for 24 h. In the other experiment, cells were treated with morphine with or without TLR4 agonist (LPS) or antagonist (TAK-242). In
RESULTS
UNASSIGNED
Chronic, acute, and escalating doses of morphine increased tumor. Morphine increased the expression of
CONCLUSION
UNASSIGNED
Morphine increases the progression of melanoma cancer and may be related to the increased expression of TLR4. Our results suggest that morphine should be used with caution in patients with melanoma.HighlightsMorphine increases the expression of TLR4 in melanoma.Morphine increases melanoma progression.These effects are mostly observed with chronic and escalating morphine administration.
Identifiants
pubmed: 36382834
doi: 10.1080/08923973.2022.2145967
doi:
Substances chimiques
Lipopolysaccharides
0
Morphine
76I7G6D29C
NF-kappa B
0
Toll-Like Receptor 4
0
Tlr4 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM