Sugar-Phosphate Toxicities Attenuate Salmonella Fitness in the Gut.
Salmonella
colitis
gastroenteritis
narrow-spectrum antimicrobial
sugar metabolism
sugar-phosphate
Journal
Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R
Informations de publication
Date de publication:
20 12 2022
20 12 2022
Historique:
pubmed:
17
11
2022
medline:
23
12
2022
entrez:
16
11
2022
Statut:
ppublish
Résumé
Pathogens are becoming resistant to antimicrobials at an increasing rate, and novel therapeutic strategies are needed. Using Salmonella as a model, we have investigated the induction of sugar-phosphate toxicity as a potential therapeutic modality. The approach entails providing a nutrient while blocking the catabolism of that nutrient, resulting in the accumulation of a toxic intermediate. We hypothesize that this build-up will decrease the fitness of the organism during infection given nutrient availability. We tested this hypothesis using mutants lacking one of seven genes whose mutation is expected to cause the accumulation of a toxic metabolic intermediate. The
Identifiants
pubmed: 36383008
doi: 10.1128/jb.00344-22
pmc: PMC9765134
doi:
Substances chimiques
Drinking Water
0
Sugars
0
Phosphates
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0034422Subventions
Organisme : NIAID NIH HHS
ID : R01 AI140541
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116119
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143288
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM068412
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI165391
Pays : United States
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