Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin.
Journal
The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356
Informations de publication
Date de publication:
05 12 2022
05 12 2022
Historique:
entrez:
16
11
2022
pubmed:
17
11
2022
medline:
19
11
2022
Statut:
ppublish
Résumé
Dishevelled exerts a molecular force that guides cell fate, but how it does so remains enigmatic. In this issue, Kang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202205069) show Dvl2 undergoes liquid-liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular condensate at the plasma membrane.
Identifiants
pubmed: 36383195
pii: 213691
doi: 10.1083/jcb.202211001
pmc: PMC9674272
pii:
doi:
Substances chimiques
Axin Protein
0
beta Catenin
0
Dishevelled Proteins
0
Axin Signaling Complex
0
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2022 Babcock and Pruitt.
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pubmed: 33860601
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pubmed: 29153704