Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
18 11 2022
Historique:
entrez: 16 11 2022
pubmed: 17 11 2022
medline: 19 11 2022
Statut: ppublish

Résumé

Chronic exposure to airborne carbon black ultrafine (nCB) particles generated from incomplete combustion of organic matter drives IL-17A-dependent emphysema. However, whether and how they alter the immune responses to lung cancer remains unknown. Here, we show that exposure to nCB particles increased PD-L1

Identifiants

pubmed: 36383649
doi: 10.1126/sciadv.abq0615
pmc: PMC9668323
doi:

Substances chimiques

Soot 0
Particulate Matter 0
Carbon 7440-44-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabq0615

Subventions

Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115454
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL155950
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK060445
Pays : United States

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Auteurs

Cheng-Yen Chang (CY)

Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Ran You (R)

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.

Dominique Armstrong (D)

Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Ashwini Bandi (A)

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Yi-Ting Cheng (YT)

Developmental Biology Program, Baylor College of Medicine, Houston, TX 77030, USA.
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.

Philip M Burkhardt (PM)

Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.

Luis Becerra-Dominguez (L)

Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.

Matthew C Madison (MC)

Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Hui-Ying Tung (HY)

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.

Zhimin Zeng (Z)

Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.

Yifan Wu (Y)

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Lizhen Song (L)

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Patricia E Phillips (PE)

Cytometry and Cell Sorting Core, Baylor College of Medicine, Houston TX 77030, USA.

Paul Porter (P)

Cytometry and Cell Sorting Core, Baylor College of Medicine, Houston TX 77030, USA.

John M Knight (JM)

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Nagireddy Putluri (N)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Xiaoyi Yuan (X)

Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA.

Daniela C Marcano (DC)

Department of Chemistry and Smalley-Curl Institute, NanoCarbon Center, The Welch Institute for Advanced Materials, and Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005 USA.

Emily A McHugh (EA)

Department of Chemistry and Smalley-Curl Institute, NanoCarbon Center, The Welch Institute for Advanced Materials, and Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005 USA.

James M Tour (JM)

Department of Chemistry and Smalley-Curl Institute, NanoCarbon Center, The Welch Institute for Advanced Materials, and Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005 USA.

Andre Catic (A)

Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.
Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.
Developmental Biology Program, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.

Laure Maneix (L)

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.

Bryan M Burt (BM)

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Division of Thoracic Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

Hyun-Sung Lee (HS)

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Division of Thoracic Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

David B Corry (DB)

Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.
Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, USA.
Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey, Baylor College of Medicine, Houston, TX 77030, USA.

Farrah Kheradmand (F)

Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.
Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, USA.
Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey, Baylor College of Medicine, Houston, TX 77030, USA.

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