Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
18 Nov 2022
18 Nov 2022
Historique:
entrez:
16
11
2022
pubmed:
17
11
2022
medline:
17
11
2022
Statut:
ppublish
Résumé
Rodents perceive pheromones via vomeronasal receptors encoded by highly evolutionarily dynamic Vr and Fpr gene superfamilies. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered organization of functional V1r and Fpr genes. We also found that V1r pseudogenes are more likely to be expressed when located in a functional V1r gene cluster than when isolated. To explore the potential regulatory role played by the association of functional vomeronasal receptor genes with their clusters, we dissociated the mouse
Identifiants
pubmed: 36383665
doi: 10.1126/sciadv.abn7450
pmc: PMC9668312
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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