Medin co-aggregates with vascular amyloid-β in Alzheimer's disease.

Animals Humans Mice Middle Aged Alzheimer Disease / metabolism Amyloid beta-Peptides / metabolism Amyloid beta-Protein Precursor / metabolism Cognitive Dysfunction Mice, Transgenic Plaque, Amyloid / metabolism tau Proteins / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
12 2022
Historique:
received: 08 02 2021
accepted: 12 10 2022
pubmed: 18 11 2022
medline: 3 12 2022
entrez: 17 11 2022
Statut: ppublish

Résumé

Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin) are found in the vasculature of almost all humans over 50 years of age

Identifiants

DOI: 10.1038/s41586-022-05440-3 PMID: 36385530 PMC: PMC9712113
pubmed: 36385530
doi: 10.1038/s41586-022-05440-3
pii: 10.1038/s41586-022-05440-3
pmc: PMC9712113
doi:

Substances chimiques

Amyloid beta-Peptides 0
Amyloid beta-Protein Precursor 0
MFGE8 protein, human 0
Mfge8 protein, mouse 0
APP protein, human 0
tau Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

123-131

Subventions

Organisme : British Heart Foundation
ID : FS/12/61/29877
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : U01 AG046152
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG015819
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG025688
Pays : United States
Organisme : British Heart Foundation
ID : F/S/12/61/29877
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG079234
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG061356
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG032984
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG036836
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015819
Pays : United States

Informations de copyright

© 2022. The Author(s).

Références

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Auteurs

Jessica Wagner (J)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany.

Karoline Degenhardt (K)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany.

Marleen Veit (M)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany.

Nikolaos Louros (N)

Switch Laboratory, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.
Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-4030-1022

Katerina Konstantoulea (K)

Switch Laboratory, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.
Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-0960-6274

Angelos Skodras (A)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Katleen Wild (K)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.

Ping Liu (P)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany.

Ulrike Obermüller (U)

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Vikas Bansal (V)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
ORCID: 0000-0002-0944-7226

Anupriya Dalmia (A)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.

Lisa M Häsler (LM)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Marius Lambert (M)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Matthias De Vleeschouwer (M)

Switch Laboratory, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.
Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

Hannah A Davies (HA)

Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool, UK.

Jillian Madine (J)

Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool, UK.
Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
ORCID: 0000-0001-9963-5871

Deborah Kronenberg-Versteeg (D)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Regina Feederle (R)

Monoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz Zentrum München, Research Center for Environmental Health, Neuherberg, Germany.
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
ORCID: 0000-0002-3981-367X

Domenico Del Turco (D)

Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Neuroscience Center, Goethe University, Frankfurt/Main, Germany.

K Peter R Nilsson (KPR)

Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.

Tammaryn Lashley (T)

Queen Square Brain Bank for Neurological Disorders, University College London Queen Square Institute of Neurology, London, UK.
Department of Neurodegenerative Disease, University College London Queen Square Institute of Neurology, London, UK.

Thomas Deller (T)

Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Neuroscience Center, Goethe University, Frankfurt/Main, Germany.

Marla Gearing (M)

Department of Pathology and Laboratory Medicine and Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.

Lary C Walker (LC)

Department of Neurology and Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
ORCID: 0000-0001-9166-3261

Peter Heutink (P)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
ORCID: 0000-0001-5218-1737

Frederic Rousseau (F)

Switch Laboratory, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.
Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-9189-7399

Joost Schymkowitz (J)

Switch Laboratory, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.
Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

Mathias Jucker (M)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
ORCID: 0000-0001-9045-1072

Jonas J Neher (JJ)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. jonas.neher@dzne.de.
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. jonas.neher@dzne.de.
ORCID: 0000-0003-1346-8924

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Medin co-aggregates with vascular amyloid-β in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Medin co-aggregates with vascular amyloid-β in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Medin co-aggregates with vascular amyloid-β in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Medin co-aggregates with vascular amyloid-β in...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Medin co-aggregates with vascular amyloid-β in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Medin co-aggregates with vascular amyloid-β in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Protéase nexines › Précurseur de la protéine bêta-amyloïde › Medin co-aggregates with vascular amyloid-β in...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Medin co-aggregates with vascular amyloid-β in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Medin co-aggregates with vascular amyloid-β in...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque amyloïde › Medin co-aggregates with vascular amyloid-β in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Medin co-aggregates with vascular amyloid-β in...