Current Concept Review: Risk Factors for Infection Following Open Fractures.
antibiotic prophylaxis
infection
open fracture
trauma
Journal
Orthopedic research and reviews
ISSN: 1179-1462
Titre abrégé: Orthop Res Rev
Pays: New Zealand
ID NLM: 101531415
Informations de publication
Date de publication:
2022
2022
Historique:
received:
03
08
2022
accepted:
01
11
2022
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
18
11
2022
Statut:
epublish
Résumé
Infection following open fracture is a significant source of morbidity and mortality. Therefore, a central tenet of treatment is to minimize the risk of infection. The initial risk of infection is determined by wound characteristics, such as size, soft tissue coverage, vascular injury, and contamination. While no consensus exists on optimal antibiotic regimen, early administration of prophylactic antibiotics, within an hour of injury, when possible, has been shown definitively to decrease the risk of infection. Infection risk is further reduced by early irrigation with normal saline and aggressive debridement of devitalized tissue. Patient factors that increase risk of infection following open fracture include diabetes mellitus, smoking, male gender, and lower extremity fracture.
Identifiants
pubmed: 36385752
doi: 10.2147/ORR.S384845
pii: 384845
pmc: PMC9651069
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
383-391Informations de copyright
© 2022 Coombs et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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