Wnt-5a induces the conversion of silent to functional synapses in the hippocampus.
AMPA receptors
NMDA postsynaptic currents
Wnt signaling
development
hippocampus
silent synapses
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
08
2022
accepted:
04
10
2022
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
18
11
2022
Statut:
epublish
Résumé
Synapse unsilencing is an essential mechanism for experience-dependent plasticity. Here, we showed that the application of the ligand Wnt-5a converts glutamatergic silent synapses into functional ones by increasing both α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) currents (I
Identifiants
pubmed: 36385757
doi: 10.3389/fnmol.2022.1024034
pmc: PMC9650636
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1024034Informations de copyright
Copyright © 2022 Álvarez-Ferradas, Wellmann, Morales, Fuenzalida, Cerpa, Inestrosa and Bonansco.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
eNeuro. 2019 May 29;6(3):
pubmed: 31110134
Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21164-9
pubmed: 21084636
Cell Rep. 2017 Oct 3;21(1):60-69
pubmed: 28978484
J Physiol. 2004 May 15;557(Pt 1):3-12
pubmed: 15034124
Dev Dyn. 2010 Jan;239(1):94-101
pubmed: 19681159
Ann N Y Acad Sci. 2003 Nov;1003:1-11
pubmed: 14684431
Nature. 1990 Jul 12;346(6280):177-80
pubmed: 2164158
Trends Neurosci. 2006 Mar;29(3):132-9
pubmed: 16443288
Nat Rev Neurosci. 2008 Nov;9(11):813-25
pubmed: 18854855
J Physiol. 2008 Mar 15;586(6):1519-27
pubmed: 18202095
J Neurosci. 2011 Apr 27;31(17):6311-6
pubmed: 21525271
J Cell Sci. 2001 Apr;114(Pt 7):1251
pubmed: 11256991
Front Cell Neurosci. 2013 Jul 04;7:103
pubmed: 23847469
Nat Neurosci. 2001 Apr;4(4):382-90
pubmed: 11276228
Soc Gen Physiol Ser. 1997;52:163-75
pubmed: 9210228
Neurodegener Dis. 2008;5(3-4):149-52
pubmed: 18322375
J Biol Chem. 2009 Jun 5;284(23):15857-66
pubmed: 19332546
Neuroscientist. 2013 Feb;19(1):62-75
pubmed: 22343826
Nature. 2012 May 27;486(7403):410-4
pubmed: 22722203
Hippocampus. 2015 Nov;25(11):1274-84
pubmed: 25727316
J Neurosci. 2011 Jun 29;31(26):9466-71
pubmed: 21715611
Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4797-802
pubmed: 25825749
Mol Neurobiol. 2016 Jan;53(1):299-309
pubmed: 25429903
J Neurophysiol. 1998 Apr;79(4):2013-24
pubmed: 9535965
FASEB J. 2011 Oct;25(10):3570-82
pubmed: 21746862
Nat Commun. 2018 Jun 11;9(1):2267
pubmed: 29891949
Neuron. 2002 Jul 18;35(2):345-53
pubmed: 12160751
Eur J Neurosci. 2011 Apr;33(8):1483-92
pubmed: 21395864
J Neurosci. 2001 Aug 15;21(16):6008-17
pubmed: 11487624
Neuron. 2011 Sep 22;71(6):1085-101
pubmed: 21943605
J Neurosci. 2012 Jun 13;32(24):8127-37
pubmed: 22699894
Brain Res. 2003 Nov 21;991(1-2):274-9
pubmed: 14575905
Neuron. 1995 Aug;15(2):427-34
pubmed: 7646894
J Neurosci. 2019 May 8;39(19):3611-3626
pubmed: 30846615
J Neurosci. 2002 Jun 1;22(11):4406-11
pubmed: 12040047
J Neurosci Res. 2013 Jan;91(1):30-41
pubmed: 23023811
Mol Neurodegener. 2010 Jan 18;5:3
pubmed: 20205789
J Physiol. 2001 Nov 15;537(Pt 1):141-9
pubmed: 11711568
Cell. 2005 Feb 11;120(3):421-33
pubmed: 15707899
Brain Res. 2015 Sep 24;1621:5-16
pubmed: 25619552
J Neurosci. 2005 Apr 20;25(16):4040-51
pubmed: 15843606
Science. 1995 Sep 22;269(5231):1730-4
pubmed: 7569903
J Neurochem. 2013 Dec;127(5):632-43
pubmed: 24032433
J Neurochem. 2010 Jul;114(1):62-73
pubmed: 20374423
Nature. 1995 Jun 1;375(6530):400-4
pubmed: 7760933
Front Cell Neurosci. 2015 Mar 25;9:95
pubmed: 25859181
Cell Tissue Res. 2015 Jan;359(1):215-23
pubmed: 25234280
Neuroscience. 2007 Jul 13;147(3):693-711
pubmed: 17582687
Hippocampus. 2011 Apr;21(4):374-85
pubmed: 20082298
Biochem Biophys Res Commun. 2014 Feb 7;444(2):189-94
pubmed: 24440698
Cell Rep. 2018 Apr 24;23(4):1060-1071
pubmed: 29694885
Neural Dev. 2009 Nov 02;4:41
pubmed: 19883499
Nature. 2005 Oct 27;437(7063):1370-5
pubmed: 16251967