Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents.
7-aza-indole
Venezuelan equine encephalitis virus (VEEV)
adaptor-associated kinase 1
pyrrolo[2,3-b]pyridine
respiratory syncytial virus (RSV)
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
09
2022
accepted:
17
10
2022
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
18
11
2022
Statut:
epublish
Résumé
RNA viral infections, including those caused by respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Venezuelan Equine encephalitis virus (VEEV), pose a major global health challenge. Here, we report the synthesis and screening of a series of pyrrolo[2,3-
Identifiants
pubmed: 36385995
doi: 10.3389/fchem.2022.1058229
pii: 1058229
pmc: PMC9643853
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1058229Subventions
Organisme : NIAID NIH HHS
ID : R01 AI158569
Pays : United States
Informations de copyright
Copyright © 2022 Martinez-Gualda, Graus, Camps, Vanhulle, Saul, Azari, Nhu Tran, Vangeel, Chiu, Neyts, Schols, Einav, Vermeire and De Jonghe.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Med Chem. 2019 Jun 27;62(12):5810-5831
pubmed: 31136173
Clin Microbiol Rev. 2008 Apr;21(2):274-90, table of contents
pubmed: 18400797
Nat Rev Microbiol. 2021 Mar;19(3):155-170
pubmed: 33116300
Pediatr Rev. 2014 Dec;35(12):519-30
pubmed: 25452661
Ann Clin Microbiol Antimicrob. 2020 May 19;19(1):19
pubmed: 32429942
J Virol Methods. 2012 Aug;183(2):176-9
pubmed: 22575574
Nat Commun. 2020 Nov 17;11(1):5838
pubmed: 33203860
N Engl J Med. 2005 Apr 28;352(17):1749-59
pubmed: 15858184
Annu Rev Microbiol. 2001;55:235-53
pubmed: 11544355
PLoS Pathog. 2012;8(8):e1002845
pubmed: 22916011
Antiviral Res. 2020 Dec;184:104966
pubmed: 33137362
J Med Chem. 2008 Feb 28;51(4):875-96
pubmed: 18254606
Viruses. 2019 Feb 18;11(2):
pubmed: 30781656
Antiviral Res. 2022 Aug;204:105367
pubmed: 35738348
J Clin Invest. 2017 Apr 3;127(4):1338-1352
pubmed: 28240606
J Virol Methods. 2005 Oct;129(1):56-63
pubmed: 15961169
Front Immunol. 2022 Apr 27;13:843928
pubmed: 35572592
Antiviral Res. 2021 Sep;193:105127
pubmed: 34217752
Pediatr Infect Dis J. 2017 Aug;36(8):808-810
pubmed: 28383391
J Virol. 2014 Feb;88(4):2035-46
pubmed: 24307590
Int J Antimicrob Agents. 1996 Aug;7(3):193-202
pubmed: 18611756
Nat Rev Microbiol. 2021 Aug;19(8):528-545
pubmed: 33753932
Curr Opin Virol. 2015 Apr;11:44-54
pubmed: 25681709
Infect Disord Drug Targets. 2012 Apr;12(2):110-28
pubmed: 22335496
J Med Chem. 2014 Oct 23;57(20):8608-21
pubmed: 25244572
Pharmacol Res. 2022 May;179:106201
pubmed: 35367622
Clin Microbiol Rev. 2017 Jan;30(1):277-319
pubmed: 27903593