Role of the mitral valve in left ventricular assist device pathophysiology.
advanced heart failure
aortic valve
functional mitral regurgitation
left ventricular assist device
mitral valve
right heart failure
transcatheter edge-to-edge therapy
tricuspid valve
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
08
2022
accepted:
29
09
2022
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
18
11
2022
Statut:
epublish
Résumé
Functional mitral regurgitation (MR) in the setting of heart failure results from progressive dilatation of the left ventricle (LV) and mitral annulus. This leads to leaflet tethering with posterior displacement. Contrary to common assumptions, MR often does not resolve with LVAD decompression of the LV alone. The negative impact of significant (moderate-severe) mitral regurgitation in the LVAD setting is becoming better recognized in terms of its harmful effect on right heart function, pulmonary vascular resistance and hospital readmissions. However, controversies remain regarding the threshold for intervention and management. At present, there are no consensus indications for the repair of significant mitral regurgitation at the time of LVAD implantation due to the conflicting data regarding potential adverse effects of MR on clinical outcomes. In this review, we summarize the current understanding of MR pathophysiology in patients supported with LVAD and potential future management strategies.
Identifiants
pubmed: 36386343
doi: 10.3389/fcvm.2022.1018295
pmc: PMC9649705
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1018295Informations de copyright
Copyright © 2022 Noly, Duggal, Jiang, Nordsletten, Bonini, Lei, Ela, Haft, Pagani, Cascino and Tang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Card Surg. 2013 Nov;28(6):770-5
pubmed: 24118109
Semin Thorac Cardiovasc Surg. 2021 Winter;33(4):988-995
pubmed: 33444766
J Am Coll Cardiol. 2015 May 12;65(18):1931-8
pubmed: 25936265
J Am Coll Cardiol. 2014 Nov 4;64(18):1883-90
pubmed: 25444141
J Am Coll Cardiol. 2019 May 21;73(19):2465-2476
pubmed: 31097168
ASAIO J. 2021 Oct 1;67(10):1139-1147
pubmed: 34570728
Pacing Clin Electrophysiol. 2022 Apr;45(4):567-570
pubmed: 35199863
J Heart Lung Transplant. 2021 Apr;40(4):316-317
pubmed: 33518453
J Artif Organs. 2019 Jun;22(2):91-97
pubmed: 30361785
J Heart Lung Transplant. 2014 Dec;33(12):1233-40
pubmed: 25108909
J Am Coll Cardiol. 2015 Mar 31;65(12):1231-1248
pubmed: 25814231
J Am Heart Assoc. 2017 Mar 8;6(3):
pubmed: 28275069
N Engl J Med. 2017 Feb 2;376(5):440-450
pubmed: 27959709
Circulation. 2006 Jul 4;114(1 Suppl):I529-34
pubmed: 16820632
Circ Cardiovasc Interv. 2015 Apr;8(4):
pubmed: 25855679
ESC Heart Fail. 2020 Jun;7(3):1085-1094
pubmed: 32196996
J Am Coll Cardiol. 2008 Mar 18;51(11):1112-9
pubmed: 18342232
N Engl J Med. 2019 May 16;380(20):1980-1981
pubmed: 31091394
JACC Clin Electrophysiol. 2016 Dec;2(7):793-798
pubmed: 29759763
J Thorac Cardiovasc Surg. 2014 Oct;148(4):1328-1333.e1
pubmed: 24332115
J Cardiol. 2016 Mar;67(3):287-94
pubmed: 26162945
J Heart Lung Transplant. 2015 May;34(5):718-23
pubmed: 25697807
Interact Cardiovasc Thorac Surg. 2017 Jun 1;24(6):828-834
pubmed: 28329284
Interact Cardiovasc Thorac Surg. 2022 Mar 31;34(4):668-675
pubmed: 34662395
J Am Coll Cardiol. 2019 Jul 9;74(1):104-132
pubmed: 30703431
J Am Coll Cardiol. 2021 Mar 2;77(8):1029-1040
pubmed: 33632476
J Cardiothorac Surg. 2019 Apr 25;14(1):80
pubmed: 31023326
Circ Heart Fail. 2014 Jan;7(1):215-22
pubmed: 24449812
Ann Thorac Surg. 2017 Mar;103(3):725-733
pubmed: 27659599
J Am Coll Cardiol. 1992 Dec;20(7):1594-8
pubmed: 1452934
N Engl J Med. 2018 Dec 13;379(24):2307-2318
pubmed: 30280640
J Neurol Sci. 2017 Nov 15;382:170-184
pubmed: 29055498
Ann Thorac Surg. 2019 Apr;107(4):1181-1186
pubmed: 30365959
J Heart Lung Transplant. 2018 Jan;37(1):79-88
pubmed: 29150326
Int J Cardiol. 2014 Feb 15;171(3):e113-6
pubmed: 24405839
N Engl J Med. 2017 Feb 2;376(5):451-460
pubmed: 28146651
Am J Cardiol. 1990 Jun 1;65(20):1372-8
pubmed: 2343826
JACC Heart Fail. 2021 Mar;9(3):179-189
pubmed: 33309575
N Engl J Med. 2016 May 19;374(20):1932-41
pubmed: 27040451
PET Clin. 2019 Apr;14(2):281-291
pubmed: 30826025
Eur J Heart Fail. 2011 May;13(5):569-76
pubmed: 21471146
Basic Res Cardiol. 2013 Nov;108(6):384
pubmed: 24072434
J Hum Hypertens. 2007 Jan;21(1):20-7
pubmed: 17096009
Semin Thorac Cardiovasc Surg. 2021 Winter;33(4):996-997
pubmed: 33609678
Circ Heart Fail. 2016 Jul;9(7):
pubmed: 27402861
Asian Cardiovasc Thorac Ann. 2020 Sep;28(7):421-426
pubmed: 32611195
Ann Thorac Surg. 2013 Mar;95(3):e59-60
pubmed: 23438564
J Heart Lung Transplant. 2014 Feb;33(2):141-8
pubmed: 23932442
Artif Organs. 2018 Dec;42(12):1139-1147
pubmed: 30101551
JACC Cardiovasc Interv. 2015 Apr 20;8(4):588-96
pubmed: 25819185
Eur J Cardiothorac Surg. 2018 Jun 1;53(6):1144-1150
pubmed: 29351635
Circulation. 2006 Aug 1;114(5):e84-231
pubmed: 16880336
J Heart Lung Transplant. 2013 Sep;32(9):897-904
pubmed: 23850122
Congest Heart Fail. 2013 Jul-Aug;19(4):165-71
pubmed: 23910701
J Am Soc Echocardiogr. 2015 Aug;28(8):853-909
pubmed: 26239899
Ann Thorac Surg. 2015 Oct;100(4):1383-9
pubmed: 26279366
ASAIO J. 2017 Jul/Aug;63(4):419-424
pubmed: 28118262
J Card Surg. 2021 Jun;36(6):1843-1849
pubmed: 33604994
JACC Heart Fail. 2015 Jul;3(7):554-564
pubmed: 26071617
Heart Rhythm. 2015 Dec;12(12):2488-98
pubmed: 26272522
J Thorac Cardiovasc Surg. 2020 Mar;159(3):897-905.e4
pubmed: 31101350
ESC Heart Fail. 2021 Apr;8(2):1039-1046
pubmed: 33471962
Cardiovasc Eng Technol. 2016 Jun;7(2):139-47
pubmed: 27008972
Int J Cardiol. 2019 Aug 1;288:55-56
pubmed: 30954287
Nat Rev Cardiol. 2016 Jul;13(7):429-40
pubmed: 27121305
Hypertension. 2008 Apr;51(4):905-14
pubmed: 18299485
Ann Transl Med. 2016 Oct;4(20):413
pubmed: 27867965
JACC Heart Fail. 2017 Feb;5(2):81-88
pubmed: 28017353
J Heart Lung Transplant. 2020 Jun;39(6):529-537
pubmed: 32279919
J Card Surg. 2014 Jul;29(4):572-80
pubmed: 24750460
J Thorac Cardiovasc Surg. 2013 May;145(5):1373-9
pubmed: 23312101
Eur J Cardiothorac Surg. 2019 Aug 1;56(2):230-270
pubmed: 31100109
J Heart Lung Transplant. 2015 Dec;34(12):1604-10
pubmed: 26163154
Catheter Cardiovasc Interv. 2021 Jun 1;97(7):E1043-E1052
pubmed: 32710470
J Am Soc Echocardiogr. 2016 Oct;29(10):946-954
pubmed: 27502042
ASAIO J. 2013 Jul-Aug;59(4):405-9
pubmed: 23820280
Circulation. 2005 Aug 30;112(9 Suppl):I396-401
pubmed: 16159853
JAMA. 2014 Nov 19;312(19):1988-98
pubmed: 25399274
J Thorac Cardiovasc Surg. 2021 Sep 14;:
pubmed: 34689984
J Thorac Cardiovasc Surg. 2019 May;157(5):1841-1848.e1
pubmed: 31288361
JACC Clin Electrophysiol. 2019 Apr;5(4):459-466
pubmed: 31000099
Eur J Heart Fail. 2019 Dec;21(12):1619-1627
pubmed: 31476260
Artif Organs. 2018 Jan;42(1):107
pubmed: 29314115
ASAIO J. 2012 Nov-Dec;58(6):574-7
pubmed: 23103696
Circulation. 2019 Jan 2;139(1):37-47
pubmed: 30586701
Eur J Heart Fail. 2012 Mar;14(3):312-8
pubmed: 22265922
J Am Coll Cardiol. 2014 Jul 8;64(1):1-12
pubmed: 24998121
Circ Res. 2016 Jun 24;119(1):159-76
pubmed: 27340274
J Am Coll Cardiol. 2012 Feb 21;59(8):703-10
pubmed: 22340261
JAMA Cardiol. 2020 Sep 1;5(9):1000-1005
pubmed: 32936270
Interact Cardiovasc Thorac Surg. 2017 Oct 1;25(4):620-623
pubmed: 28962504
J Card Surg. 2021 Jun;36(6):2081-2094
pubmed: 33772887
J Heart Lung Transplant. 2020 Jun;39(6):538-540
pubmed: 32307247
J Heart Lung Transplant. 2020 Dec;39(12):1353-1362
pubmed: 33008726
J Thorac Cardiovasc Surg. 2010 May;139(5):1316-24
pubmed: 20132950
Circulation. 2019 May 14;139(20):e967-e989
pubmed: 30943783
ASAIO J. 2013 Sep-Oct;59(5):469-73
pubmed: 23896769
J Thorac Cardiovasc Surg. 2019 May;157(5):1851-1860.e1
pubmed: 30739772
J Am Coll Cardiol. 2010 Jan 26;55(4):271-82
pubmed: 20117430
Semin Cardiothorac Vasc Anesth. 2019 Mar;23(1):134-139
pubmed: 30014773
J Heart Lung Transplant. 2015 Dec;34(12):1595-603
pubmed: 26123950
J Thorac Cardiovasc Surg. 2018 Mar;155(3):995-996
pubmed: 29089092
Am J Cardiol. 1996 Apr 1;77(9):769-74
pubmed: 8651134
J Heart Lung Transplant. 2013 Feb;32(2):157-87
pubmed: 23352391
J Am Heart Assoc. 2018 May 17;7(11):
pubmed: 29773577