Prevalence of left ventricular hypertrophy in children and young people with primary hypertension: Meta-analysis and meta-regression.
adolescents
children
left ventricular hypertrophy
left ventricular mass index
primary hypertension
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
07
2022
accepted:
05
10
2022
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
18
11
2022
Statut:
epublish
Résumé
Left ventricular hypertrophy (LVH) is the main marker of HMOD in children and young people (CYP). We aimed to assess the prevalence of LVH and its determinants in CYP with primary hypertension (PH). A meta-analysis of prevalence was performed. A literature search of articles reporting LVH in CYP with PH was conducted in Medline, Embase, and Cochrane databases. Studies with a primary focus on CYP (up to 21 years) with PH were included. Meta-regression was used to analyze factors explaining observed heterogeneity. The search yielded a total of 2,200 articles, 153 of those underwent full-text review, and 47 reports were included. The reports evaluated 51 study cohorts including 5,622 individuals, 73% male subjects, and a mean age of 13.6 years. LVH was defined as left ventricle mass index (LVMI) ≥ 95th percentile in 22 (47%), fixed cut-off ≥38.6 g/m Left ventricular hypertrophy is evident in at least one-fifth of children and young adults with PH and in nearly a third of those referred to specialty clinics with a predominant eccentric LVH pattern in the latter. Increased BMI is the most significant risk association for LVH in hypertensive youth.
Sections du résumé
Background
UNASSIGNED
Left ventricular hypertrophy (LVH) is the main marker of HMOD in children and young people (CYP). We aimed to assess the prevalence of LVH and its determinants in CYP with primary hypertension (PH).
Methods
UNASSIGNED
A meta-analysis of prevalence was performed. A literature search of articles reporting LVH in CYP with PH was conducted in Medline, Embase, and Cochrane databases. Studies with a primary focus on CYP (up to 21 years) with PH were included. Meta-regression was used to analyze factors explaining observed heterogeneity.
Results
UNASSIGNED
The search yielded a total of 2,200 articles, 153 of those underwent full-text review, and 47 reports were included. The reports evaluated 51 study cohorts including 5,622 individuals, 73% male subjects, and a mean age of 13.6 years. LVH was defined as left ventricle mass index (LVMI) ≥ 95th percentile in 22 (47%), fixed cut-off ≥38.6 g/m
Conclusion
UNASSIGNED
Left ventricular hypertrophy is evident in at least one-fifth of children and young adults with PH and in nearly a third of those referred to specialty clinics with a predominant eccentric LVH pattern in the latter. Increased BMI is the most significant risk association for LVH in hypertensive youth.
Identifiants
pubmed: 36386367
doi: 10.3389/fcvm.2022.993513
pmc: PMC9659762
doi:
Types de publication
Systematic Review
Langues
eng
Pagination
993513Investigateurs
Michael Hecht Olsen
(MH)
Katerina Chrysaidou
(K)
Asle Hirth
(A)
Giacomo Simonetti
(G)
Kjell Tullus
(K)
Rina Rus
(R)
Verónica Martínez
(V)
Empar Lurbe
(E)
Elke Wuhl
(E)
Veronica Martinez Rivera
(VM)
Informations de copyright
Copyright © 2022 Sinha, Azukaitis, Sladowska-Kozłowska, Bårdsen, Merkevicius, Karlsen Sletten, Obrycki, Pac, Fernández-Aranda, Bjelakovic, Jankauskiene, Litwin and HyperChildNet Working Group.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Hypertens. 2022 Feb 1;40(2):197-204
pubmed: 34475347
Pediatrics. 2017 Sep;140(3):
pubmed: 28827377
Ann Intern Med. 1991 Mar 1;114(5):345-52
pubmed: 1825164
Hypertension. 2006 Jul;48(1):40-4
pubmed: 16735644
Circulation. 1995 May 1;91(9):2400-6
pubmed: 7729027
Lancet. 2021 Sep 11;398(10304):957-980
pubmed: 34450083
Lancet. 1982 May 22;1(8282):1165-8
pubmed: 6122945
Hypertension. 2018 Jul;72(1):93-101
pubmed: 29785961
Clin Hypertens. 2015 Oct 22;21:21
pubmed: 26893931
Pediatr Nephrol. 2015 Dec;30(12):2189-97
pubmed: 26227630
Hypertension. 2007 Aug;50(2):392-5
pubmed: 17592068
Int J Health Policy Manag. 2014 Aug 13;3(3):123-8
pubmed: 25197676
Pediatr Cardiol. 2007 Jan-Feb;28(1):27-33
pubmed: 17308944
J Clin Hypertens (Greenwich). 2016 Jul;18(7):625-33
pubmed: 26530452
Pediatr Nephrol. 2008 May;23(5):787-96
pubmed: 18253758
J Hypertens. 2019 Apr;37(4):732-738
pubmed: 30817454
Prog Cardiovasc Dis. 2020 Jan - Feb;63(1):10-21
pubmed: 31759953
Am J Hypertens. 2010 Jan;23(1):24-9
pubmed: 19851297
Circulation. 1978 Feb;57(2):278-85
pubmed: 618615
J Hypertens. 2016 Sep;34(9):1815-22
pubmed: 27379542
J Hypertens. 2022 Jul 1;40(7):1369-1379
pubmed: 35762477
Front Pediatr. 2021 Nov 15;9:785356
pubmed: 34869128
J Hum Hypertens. 2020 May;34(5):355-363
pubmed: 30926902
JAMA Pediatr. 2019 Dec 1;173(12):1154-1163
pubmed: 31589252
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
J Hypertens. 2019 Jun;37(6):1213-1222
pubmed: 31022109
Hypertension. 2020 Mar;75(3):826-834
pubmed: 31884853
J Am Soc Hypertens. 2009 Nov-Dec;3(6):416-23
pubmed: 20409984
Am Heart J. 2000 Dec;140(6):848-56
pubmed: 11099987
Eur Heart J Cardiovasc Imaging. 2022 Nov 17;23(12):1645-1653
pubmed: 34931224
Pediatr Nephrol. 2006 Jun;21(6):811-9
pubmed: 16565870
Sci Rep. 2021 Nov 9;11(1):21943
pubmed: 34753958
Curr Hypertens Rep. 2020 Sep 5;22(10):85
pubmed: 32889649
J Hypertens. 2021 Apr 1;39(4):711-717
pubmed: 33201051
BMC Cardiovasc Disord. 2020 Jun 16;20(1):296
pubmed: 32546130
JACC Heart Fail. 2017 Aug;5(8):543-551
pubmed: 28711447
Clin Cardiol. 1993 May;16(5 Suppl 2):II10-4
pubmed: 8504584
J Pediatr. 2020 Feb;217:152-157
pubmed: 31810626
Blood Press Monit. 1999 Jun-Aug;4(3-4):165-70
pubmed: 10490869
Arch Pediatr. 2021 Aug;28(6):451-458
pubmed: 34226065
Pediatr Cardiol. 2008 May;29(3):580-4
pubmed: 18046596
Pediatr Nephrol. 2013 Oct;28(10):2015-22
pubmed: 23703719
J Pediatr. 2008 Jul;153(1):50-4
pubmed: 18571535
Am J Hypertens. 1998 Apr;11(4 Pt 1):410-7
pubmed: 9607378
Ann Intern Med. 1969 Jul;71(1):89-105
pubmed: 4239887
J Am Coll Cardiol. 1993 Mar 15;21(4):997-1001
pubmed: 8450171
Blood Press. 2015;24(5):284-92
pubmed: 26024395
J Hypertens. 2015 Jan;33(1):24-32
pubmed: 25380162
J Hum Hypertens. 2012 Jun;26(6):343-9
pubmed: 22113443
Pediatr Nephrol. 2013 Aug;28(8):1275-82
pubmed: 23564040
J Pediatr. 2008 Jan;152(1):73-8, 78.e1
pubmed: 18154904
Circulation. 2000 Jul 25;102(4):470-9
pubmed: 10908222
Pediatr Nephrol. 2010 Sep;25(9):1711-8
pubmed: 20495830
J Intern Med. 2002 Nov;252(5):430-9
pubmed: 12528761
J Hypertens. 2016 Oct;34(10):1887-920
pubmed: 27467768
Hypertension. 2019 Sep;74(3):590-596
pubmed: 31327264
Pediatr Nephrol. 2011 Dec;26(12):2201-9
pubmed: 21626453
Pediatr Nephrol. 2010 Dec;25(12):2489-99
pubmed: 20730452
Pediatr Nephrol. 2005 Jul;20(7):961-6
pubmed: 15864653
J Am Soc Hypertens. 2016 Feb;10(2):108-14
pubmed: 26725015
J Hypertens. 2022 May 1;40(5):985-995
pubmed: 35191414
J Hum Hypertens. 2020 Apr;34(4):319-325
pubmed: 31253844
J Hypertens. 2015 Jun;33(6):1182-92
pubmed: 25715095
Hypertension. 2002 Apr;39(4):903-8
pubmed: 11967247
J Am Heart Assoc. 2020 Jun 16;9(12):e015097
pubmed: 32508192
Am J Hypertens. 2007 Sep;20(9):990-6
pubmed: 17765141
J Hum Hypertens. 2022 Jul;36(7):604-609
pubmed: 34999719
Pediatrics. 2003 Jan;111(1):61-6
pubmed: 12509555
Pediatr Nephrol. 2009 Aug;24(8):1545-51
pubmed: 19444486
Hypertension. 2004 Apr;43(4):731-8
pubmed: 15007041
Hypertens Res. 2017 Jun;40(6):606-612
pubmed: 28123182
Front Pediatr. 2021 May 19;9:576005
pubmed: 34095018
Circulation. 1998 May 19;97(19):1907-11
pubmed: 9609083
Kardiol Pol. 2015;73(3):194-200
pubmed: 25299400
Am J Hypertens. 2007 Aug;20(8):875-82
pubmed: 17679036
Pediatrics. 2010 Nov;126(5):931-7
pubmed: 20956429
Am J Hypertens. 2016 Mar;29(3):379-87
pubmed: 26271107
J Am Soc Echocardiogr. 2009 Jun;22(6):709-14
pubmed: 19423289
Pediatr Nephrol. 2017 Sep;32(9):1585-1594
pubmed: 28411317
Am J Hypertens. 2005 Feb;18(2 Pt 1):191-6
pubmed: 15752946
Hypertension. 2006 Jul;48(1):33-9
pubmed: 16769996
Lancet Diabetes Endocrinol. 2014 Aug;2(8):634-47
pubmed: 24842598
J Clin Hypertens (Greenwich). 2015 Oct;17(10):760-6
pubmed: 26140344
Hypertension. 2000 Feb;35(2):580-6
pubmed: 10679501
Hypertension. 2013 Oct;62(4):782-8
pubmed: 23959553
Int J Cardiol. 2018 Nov 1;270:302-308
pubmed: 29908829
Cardiovasc Ultrasound. 2021 Jul 21;19(1):26
pubmed: 34289865
Pediatr Nephrol. 2019 Apr;34(4):703-712
pubmed: 30426220
Hypertension. 2004 Feb;43(2):214-8
pubmed: 14744920
Hypertension. 2013 Feb;61(2):431-6
pubmed: 23266543
Front Pediatr. 2021 Apr 07;9:620158
pubmed: 33898356
Am Heart J. 2001 Mar;141(3):334-41
pubmed: 11231428
Hypertension. 2002 Feb;39(2 Pt 2):710-4
pubmed: 11882636
J Clin Hypertens (Greenwich). 2019 May;21(5):566-571
pubmed: 30980607
J Am Soc Hypertens. 2014 May;8(5):303-11
pubmed: 24685005