A time-restricted feeding intervention in children and adolescents with obesity: The TRansForm study protocol.
actigraphy
childhood obesity
circadian rhythm
gut microbiota
time-restricted feeding (TRF)
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
08
2022
accepted:
04
10
2022
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
18
11
2022
Statut:
epublish
Résumé
Obesity during childhood is of special concern as adiposity is typically tracked into adult life and it constitutes a major risk factor for future obesity and associated metabolic disorders. Recent studies indicate that time-restricted feeding (TRF) interventions may provide a promising strategy for obesity treatment. However, TRF interventions have only been tested in adult subjects. This study aims to determine both short- and long-term effects of a TRF intervention in children and adolescents with obesity. We will also investigate potential mechanisms mediating the response to the intervention, including the circadian rhythm and the gut microbiota composition. We have designed a randomized-controlled parallel-group clinical study in which children and adolescents (age range 8-18 year-old) with obesity will be subjected to time-restricted eating or no time restrictions for 2 months. Follow-up visits will allow for long-term effect assessments. We will measure anthropometric (BMI, body composition) and metabolic parameters (glucose and lipid metabolism), indicators of the circadian rhythm, and gut microbiota composition will be analyzed. This study will (1) determine safety and effectiveness of the TRF intervention in children and adolescents; (2) assess its long-term effects; and (3) evaluate potential mechanisms involved in the response to the intervention. [www.ClinicalTrials.gov], identifier [NCT05174871].
Identifiants
pubmed: 36386926
doi: 10.3389/fnut.2022.1026694
pmc: PMC9644044
doi:
Banques de données
ClinicalTrials.gov
['NCT05174871']
Types de publication
Journal Article
Langues
eng
Pagination
1026694Informations de copyright
Copyright © 2022 Molina-Giraldo, Murillo, Meis, Sans, Amat-Bou, Llobet, Jimenez-Chillaron, Ramon-Krauel and Lerin.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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