Hemophagocytic lymphohistiocytosis as an etiology of bone marrow failure.
bone marrow failure (BMF)
cytopenia
familial hemophagocytic lymphohistiocytosis (FHL)
hemophagocytic lymphohistiocytosis
hypercytokinaemia
macrophage activation syndrome (MAS)
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
08
2022
accepted:
27
09
2022
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
18
11
2022
Statut:
epublish
Résumé
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of multiorgan system dysfunction that is caused by hypercytokinemia and persistent activation of cytotoxic T lymphocytes and macrophages. A nearly ubiquitous finding and a diagnostic criterion of HLH is the presence of cytopenias in ≥ 2 cell lines. The mechanism of cytopenias in HLH is multifactorial but appears to be predominantly driven by suppression of hematopoiesis by pro-inflammatory cytokines and, to some extent, by consumptive hemophagocytosis. Recognition of cytopenias as a manifestation of HLH is an important consideration for patients with bone marrow failure of unclear etiology.
Identifiants
pubmed: 36387094
doi: 10.3389/fonc.2022.1016318
pmc: PMC9647152
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1016318Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL007574
Pays : United States
Informations de copyright
Copyright © 2022 Paolino, Berliner and Degar.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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