Case report: Immunovirotherapy as a novel add-on treatment in a patient with thoracic NUT carcinoma.
BRD3
NUT carcinoma
NUTM1
T-VEC
chemotherapy
immunotherapy
virotherapy
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
07
2022
accepted:
10
10
2022
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
18
11
2022
Statut:
epublish
Résumé
NUT carcinoma (NC) is a rare and extremely aggressive form of cancer, usually presenting with intrathoracic or neck manifestations in adolescents and young adults. With no established standard therapy regimen and a median overall survival of only 6.5 months, there is a huge need for innovative treatment options. As NC is genetically driven by a single aberrant fusion oncoprotein, it is generally characterized by a low tumor mutational burden, thus making it immunologically cold and insusceptible to conventional immunotherapy. Recently, we have demonstrated that oncolytic viruses (OVs) are able to specifically infect and lyse NC cells, thereby turning an immunologically cold tumor microenvironment into a hot one. Here, we report an intensive multimodal treatment approach employing for the first time an OV (talimogene laherparepvec (T-VEC); IMLYGIC
Identifiants
pubmed: 36387105
doi: 10.3389/fonc.2022.995744
pmc: PMC9647065
doi:
Types de publication
Case Reports
Langues
eng
Pagination
995744Informations de copyright
Copyright © 2022 Kloker, Calukovic, Benzler, Golf, Böhm, Günther, Horger, Haas, Berchtold, Beil, Carter, Ganzenmueller, Singer, Agaimy, Stöhr, Hartmann, Duell, Mairhofer, Fohrer, Reinmuth, Zender and Lauer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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