Clinical features of biliary tract cancer in Japanese individuals with Lynch syndrome.
Lynch syndrome (LS)
biliary tract cancer (BTC)
cumulative risk
microsatellite instability (MSI)
mismatch repair gene (MMR gene)
Journal
Journal of gastrointestinal oncology
ISSN: 2078-6891
Titre abrégé: J Gastrointest Oncol
Pays: China
ID NLM: 101557751
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
23
02
2022
accepted:
02
08
2022
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
18
11
2022
Statut:
ppublish
Résumé
Biliary tract cancer (BTC) is a Lynch syndrome (LS)-associated cancer with a high mortality rate. This study aimed to clarify the clinical features of BTC in individuals with LS and to discuss its management. We obtained data from genetically verified Japanese individuals with LS who were diagnosed at a single institution, between January 2003 and April 2021. Moreover, 21 individuals with sporadic BTC (n=15) and LS associated BTC (n=6) underwent microsatellite instability (MSI) testing. Among 92 individuals with LS, 6 individuals with MSI analysis could facilitate LS identification in individuals with BTC. Surveillance for BTC should be considered for
Sections du résumé
Background
UNASSIGNED
Biliary tract cancer (BTC) is a Lynch syndrome (LS)-associated cancer with a high mortality rate. This study aimed to clarify the clinical features of BTC in individuals with LS and to discuss its management.
Methods
UNASSIGNED
We obtained data from genetically verified Japanese individuals with LS who were diagnosed at a single institution, between January 2003 and April 2021. Moreover, 21 individuals with sporadic BTC (n=15) and LS associated BTC (n=6) underwent microsatellite instability (MSI) testing.
Results
UNASSIGNED
Among 92 individuals with LS, 6 individuals with
Conclusions
UNASSIGNED
MSI analysis could facilitate LS identification in individuals with BTC. Surveillance for BTC should be considered for
Identifiants
pubmed: 36388648
doi: 10.21037/jgo-22-165
pii: jgo-13-05-2532
pmc: PMC9660066
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2532-2538Informations de copyright
2022 Journal of Gastrointestinal Oncology. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jgo.amegroups.com/article/view/10.21037/jgo-22-165/coif). KA had lecture fee from Merck Sharp & Dohme (MSD). The other authors have no conflicts of interest to declare.
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