Uganda Genome Resource: A rich research database for genomic studies of communicable and non-communicable diseases in Africa.
GPC
NCDs
Uganda
general population cohort
genomics
non-communicable diseases
Journal
Cell genomics
ISSN: 2666-979X
Titre abrégé: Cell Genom
Pays: United States
ID NLM: 9918284260106676
Informations de publication
Date de publication:
09 Nov 2022
09 Nov 2022
Historique:
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
18
11
2022
Statut:
epublish
Résumé
The Uganda Genome Resource (UGR) is a well-characterized genomic database with a range of phenotypic communicable and non-communicable diseases and risk factors generated from the Uganda General Population Cohort (GPC), a population-based open cohort established in 1989. The UGR comprises genotype data on ∼5,000 and whole-genome sequence data on ∼2,000 Ugandan GPC individuals from 10 ethno-linguistic groups. Leveraging other platforms at MRC/UVRI and LSHTM Uganda Research Unit, there is opportunity for additional sample collection to expand the UGR to advance scientific discoveries. Here, we describe UGR and highlight how it is providing opportunities for discovery of novel disease susceptibility genetic loci, refining association signals at new and existing loci, developing and testing polygenic scores to determine disease risk, assessing causal relations in diseases, and developing capacity for genomics research in Africa. The UGR has the potential to develop to a comparable level of European and Asian large-scale genomic initiatives.
Identifiants
pubmed: 36388767
doi: 10.1016/j.xgen.2022.100209
pii: S2666-979X(22)00162-8
pmc: PMC9646479
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
NoneSubventions
Organisme : Medical Research Council
ID : MC_EX_MR/L016273/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1204/16
Pays : United Kingdom
Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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