Glycosylation network mapping and site-specific glycan maturation
Cell biology
Integrative aspects of cell biology
Mathematical biosciences
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
18 Nov 2022
18 Nov 2022
Historique:
received:
26
05
2022
revised:
12
09
2022
accepted:
18
10
2022
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
18
11
2022
Statut:
epublish
Résumé
Glycoprotein processing along a complex highly compartmentalized pathway is a hallmark of eukaryotic cells. We followed the kinetics of intracellular, site-specific glycan processing of a model protein with five distinct N-glycosylation sites and deduced a mathematical model of the secretory pathway that describes a complex set of processing reactions localized in defined intracellular compartments such as the endoplasmic reticulum the Golgi, or the lysosome. The model was able to accommodate site-specific N-glycan processing and we identified phosphorylated glycan structures of the mannose-6-phosphate pathway responsible for the lysosomal sorting of the glycoprotein. Importantly, our model protein can take different routes of the cellular secretory pathway, resulting in an increased glycan complexity of the secreted protein.
Identifiants
pubmed: 36388954
doi: 10.1016/j.isci.2022.105417
pii: S2589-0042(22)01689-3
pmc: PMC9650029
doi:
Types de publication
Journal Article
Langues
eng
Pagination
105417Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
Glycobiology. 2015 Dec;25(12):1335-49
pubmed: 26240167
Cell. 2009 Jan 23;136(2):272-83
pubmed: 19167329
FASEB J. 2017 Oct;31(10):4623-4635
pubmed: 28679530
J Biol Chem. 1994 May 20;269(20):14490-6
pubmed: 8182054
Cold Spring Harb Perspect Biol. 2011 Sep 01;3(9):a005363
pubmed: 21768608
PLoS One. 2016 Jul 26;11(7):e0159859
pubmed: 27459092
Cold Spring Harb Perspect Biol. 2013 Aug 01;5(8):a013359
pubmed: 23751184
Mol Biol Cell. 1996 Dec;7(12):1909-19
pubmed: 8970154
Nat Methods. 2009 May;6(5):359-62
pubmed: 19377485
Annu Rev Anal Chem (Palo Alto Calif). 2015;8:463-83
pubmed: 26070719
Sci Adv. 2019 Nov 27;5(11):eaax8930
pubmed: 31807707
J Cell Biol. 1993 Jul;122(1):39-51
pubmed: 8314846
J Cell Sci. 1995 Apr;108 ( Pt 4):1617-27
pubmed: 7615680
Biochim Biophys Acta. 2009 Apr;1793(4):605-14
pubmed: 19046998
Semin Cell Dev Biol. 2014 Jul;31:2-10
pubmed: 24709024
RSC Chem Biol. 2021 Apr 16;2(3):917-931
pubmed: 34212152
J Cell Biol. 2004 Jun 7;165(5):735-46
pubmed: 15173190
Curr Opin Cell Biol. 2011 Apr;23(2):176-83
pubmed: 21075612
Org Biomol Chem. 2017 Oct 31;15(42):8946-8951
pubmed: 29043371
J Agric Food Chem. 2020 Nov 11;68(45):12692-12701
pubmed: 33137256
Biotechnol Rep (Amst). 2020 Jan 22;25:e00424
pubmed: 32071892
Semin Cell Dev Biol. 2015 May;41:71-8
pubmed: 25460543
Biotechnol Bioeng. 2014 Oct;111(10):2095-106
pubmed: 24771076
Int J Microbiol. 2010;2010:148178
pubmed: 21490701
Science. 2018 Feb 2;359(6375):545-550
pubmed: 29301962
Mol Biol Cell. 1998 Jul;9(7):1617-26
pubmed: 9658158
Sci Rep. 2016 Jun 27;6:28547
pubmed: 27345611
Ciba Found Symp. 1982;(92):138-56
pubmed: 6295719
Glycobiology. 2011 Jul;21(7):853-63
pubmed: 21112967
J Biol Chem. 1981 Dec 25;256(24):13060-7
pubmed: 7309750
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2233-7
pubmed: 2951738
Essays Biochem. 2017 Dec 12;61(6):625-635
pubmed: 29233873
J Biol Chem. 2020 Sep 4;295(36):12648-12660
pubmed: 32665399
Cell. 1987 Jul 17;50(2):181-92
pubmed: 2954652
Chemistry. 2018 Jul 11;24(39):9983-9992
pubmed: 29797675
J Phys Chem B. 2021 Aug 26;125(33):9467-9479
pubmed: 34379416
Cell. 1985 Feb;40(2):463-72
pubmed: 3155653
Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13204-13209
pubmed: 30530663
Trends Cell Biol. 2016 May;26(5):379-388
pubmed: 26832820
Arch Biochem Biophys. 1983 Apr 1;222(1):145-9
pubmed: 6301379
Nat Immunol. 2008 Jun;9(6):593-601
pubmed: 18490910
Curr Opin Struct Biol. 2012 Oct;22(5):558-62
pubmed: 22819743
J Biol Chem. 1986 May 15;261(14):6326-31
pubmed: 2939075
J Biol Chem. 2010 Feb 19;285(8):5759-75
pubmed: 19951948
J Cell Biol. 1991 Feb;112(4):567-77
pubmed: 1847146
Mol Cell. 2019 Jul 25;75(2):394-407.e5
pubmed: 31227230
J Proteome Res. 2004 May-Jun;3(3):556-66
pubmed: 15253437
Trends Cell Biol. 1998 Jan;8(1):34-40
pubmed: 9695806
Mol Biol Cell. 2019 Oct 1;30(21):2626-2638
pubmed: 31433728
Adv Exp Med Biol. 2018;1104:119-147
pubmed: 30484247
Glycobiology. 2012 Oct;22(10):1282-8
pubmed: 22641772
J Biol Chem. 1982 Sep 25;257(18):10605-12
pubmed: 7107630
J Biol Chem. 1989 Jul 25;264(21):12115-8
pubmed: 2545698
Analyst. 2020 Apr 14;145(8):3136-3147
pubmed: 32186558
Mol Cell. 2012 May 25;46(4):542-8
pubmed: 22633491
J Biol Chem. 1986 Nov 25;261(33):15582-90
pubmed: 3536907
Cell. 1982 Sep;30(2):439-48
pubmed: 6754086
Mass Spectrom Rev. 2019 Aug;38(4-5):356-379
pubmed: 30605224
Int J Biochem Cell Biol. 2012 May;44(5):718-21
pubmed: 22309943
Histol Histopathol. 2006 Aug;21(8):899-913
pubmed: 16691542
Nat Rev Mol Cell Biol. 2012 Jun 22;13(7):448-62
pubmed: 22722607