Human Gut Metagenomes Encode Diverse GH156 Sialidases.
GH156
glycoside hydrolase
human microbiome
inflammatory bowel disease
microbiome
sialic acid
sialidase
Journal
Applied and environmental microbiology
ISSN: 1098-5336
Titre abrégé: Appl Environ Microbiol
Pays: United States
ID NLM: 7605801
Informations de publication
Date de publication:
13 12 2022
13 12 2022
Historique:
pubmed:
18
11
2022
medline:
16
12
2022
entrez:
17
11
2022
Statut:
ppublish
Résumé
The intestinal lining is protected by a mucous barrier composed predominantly of complex carbohydrates. Gut microbes employ diverse glycoside hydrolases (GHs) to liberate mucosal sugars as a nutrient source to facilitate host colonization. Intensive catabolism of mucosal glycans, however, may contribute to barrier erosion, pathogen encroachment, and inflammation. Sialic acid is an acidic sugar featured at terminal positions of host glycans. Characterized sialidases from the microbiome belong to the GH33 family, according to CAZy (Carbohydrate-Active enZYmes Database). In 2018 a functional metagenomics screen using thermal spring DNA uncovered the founding member of the GH156 sialidase family, the presence of which has yet to be reported in the context of the human microbiome. A subset of GH156 sequences from the CAZy database containing key sialidase residues was used to build a hidden Markov model. HMMsearch against public databases revealed ~10× more putative GH156 sialidases than currently cataloged by CAZy. Represented phyla include
Identifiants
pubmed: 36394327
doi: 10.1128/aem.01755-22
pmc: PMC9746317
doi:
Substances chimiques
Glycoside Hydrolases
EC 3.2.1.-
Neuraminidase
EC 3.2.1.18
Polysaccharides
0
Sialic Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0175522Références
Nature. 1970 Aug 15;227(5259):680-5
pubmed: 5432063
Nucleic Acids Res. 2020 Sep 18;48(16):8883-8900
pubmed: 32766782
Cell Host Microbe. 2017 Apr 12;21(4):433-442
pubmed: 28407481
Nat Genet. 2022 Feb;54(2):143-151
pubmed: 35115690
Environ Microbiol. 2021 Jan;23(1):15-35
pubmed: 33185970
Annu Rev Biochem. 2020 Jun 20;89:769-793
pubmed: 32243763
Nat Rev Microbiol. 2020 Sep;18(9):521-538
pubmed: 32457482
Bioinformatics. 2012 Dec 1;28(23):3150-2
pubmed: 23060610
In Silico Biol. 2009;9(1-2):S41-55
pubmed: 19537164
Bioinformatics. 2006 Jul 1;22(13):1658-9
pubmed: 16731699
Nature. 2022 Jun;606(7913):358-367
pubmed: 35477154
Nat Commun. 2020 Aug 11;11(1):4017
pubmed: 32782292
Trends Microbiol. 2021 Sep;29(9):768-771
pubmed: 33612397
Nat Commun. 2015 Mar 25;6:6505
pubmed: 25807110
Nat Rev Drug Discov. 2021 Mar;20(3):217-243
pubmed: 33462432
Microb Genom. 2020 Mar;6(3):
pubmed: 32124724
Nature. 2012 Jun 13;486(7402):207-14
pubmed: 22699609
Glycobiology. 2021 Jun 29;31(6):697-706
pubmed: 32518945
FEBS Lett. 2014 Nov 17;588(22):4223-33
pubmed: 25307765
Curr Biol. 2015 Jun 29;25(13):1682-93
pubmed: 25981789
Cell Res. 2020 Jun;30(6):492-506
pubmed: 32433595
Biochim Biophys Acta. 2015 Aug;1854(8):1019-37
pubmed: 25900361
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Nat Rev Gastroenterol Hepatol. 2015 Apr;12(4):205-17
pubmed: 25732745
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
J Clin Invest. 2011 Apr;121(4):1657-66
pubmed: 21383503
Mucosal Immunol. 2019 Jan;12(1):1-9
pubmed: 29988120
Nat Rev Microbiol. 2016 Jan;14(1):20-32
pubmed: 26499895
Glycobiology. 2021 Jun 29;31(6):691-696
pubmed: 33043970
Exp Mol Med. 2021 May;53(5):772-787
pubmed: 34002011
Sci Rep. 2016 Sep 14;6:32826
pubmed: 27624970
Nat Methods. 2022 Jun;19(6):679-682
pubmed: 35637307
Microbiology (Reading). 2013 Apr;159(Pt 4):649-664
pubmed: 23460033
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15064-9
pubmed: 18806221
Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6063-6068
pubmed: 30850540
Nat Biotechnol. 2021 Apr;39(4):499-509
pubmed: 33169036
Inflamm Bowel Dis. 2011 Nov;17(11):2299-307
pubmed: 21290483
Adv Exp Med Biol. 2021;1325:265-283
pubmed: 34495540
Appl Environ Microbiol. 2021 Feb 26;87(6):
pubmed: 33452027
Cell Host Microbe. 2015 Oct 14;18(4):478-88
pubmed: 26439864
Nature. 2010 Mar 4;464(7285):59-65
pubmed: 20203603
Nucleic Acids Res. 2009 Jan;37(Database issue):D233-8
pubmed: 18838391
Nat Microbiol. 2019 Sep;4(9):1475-1485
pubmed: 31182795
Nat Genet. 2021 Feb;53(2):147-155
pubmed: 33462482
BMC Evol Biol. 2012 Sep 20;12:186
pubmed: 22992189
Nature. 2017 Apr 6;544(7648):65-70
pubmed: 28329766
Gigascience. 2021 Feb 16;10(2):
pubmed: 33590861
Science. 2005 Mar 25;307(5717):1955-9
pubmed: 15790854
Nat Microbiol. 2019 Feb;4(2):293-305
pubmed: 30531976
Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1;315(3):G420-G431
pubmed: 29848021
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Trends Microbiol. 2022 Jan;30(1):13-21
pubmed: 34217596
Trends Microbiol. 2021 Feb;29(2):142-157
pubmed: 32950378
Cell Immunol. 2018 Nov;333:9-18
pubmed: 30049413
Bioinformatics. 2018 May 15;34(10):1719-1725
pubmed: 29281009
PLoS Pathog. 2017 Jan 5;13(1):e1006090
pubmed: 28056108
Curr Opin Chem Biol. 2019 Dec;53:82-87
pubmed: 31550558
Nat Chem Biol. 2020 Dec;16(12):1376-1384
pubmed: 32807964
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Nat Rev Microbiol. 2022 Sep;20(9):542-556
pubmed: 35347288
Gastroenterology. 2017 Feb;152(2):313-321.e2
pubmed: 27793607
Biochem J. 1991 Dec 1;280 ( Pt 2):309-16
pubmed: 1747104
Nat Commun. 2019 Oct 23;10(1):4816
pubmed: 31645552
Nat Commun. 2015 Aug 25;6:8141
pubmed: 26303108
Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14787-14792
pubmed: 27930307
J Biol Chem. 2018 Nov 23;293(47):18138-18150
pubmed: 30249617
Nat Microbiol. 2019 Sep;4(9):1571-1581
pubmed: 31160824
PLoS Comput Biol. 2011 Oct;7(10):e1002195
pubmed: 22039361
Science. 2017 Aug 25;357(6353):802-806
pubmed: 28839072
Curr Opin Gastroenterol. 2017 Jul;33(4):222-229
pubmed: 28402995
Gastroenterology. 2006 Jul;131(1):117-29
pubmed: 16831596
PLoS One. 2014 Jan 09;9(1):e85254
pubmed: 24416370
PLoS Pathog. 2022 Apr 28;18(4):e1010167
pubmed: 35482787
Biochem Soc Trans. 2016 Feb;44(1):166-75
pubmed: 26862202
Nucleic Acids Res. 2022 Jan 7;50(D1):D571-D577
pubmed: 34850161
Cell. 2016 Nov 17;167(5):1339-1353.e21
pubmed: 27863247
ISME J. 2021 Feb;15(2):577-591
pubmed: 33087860
FEMS Microbiol Rev. 2018 Nov 1;42(6):739-760
pubmed: 30052954
Cell Host Microbe. 2008 Nov 13;4(5):447-57
pubmed: 18996345
PLoS Pathog. 2022 Apr 28;18(4):e1010407
pubmed: 35482710
Protein Eng Des Sel. 2006 Dec;19(12):555-62
pubmed: 17085431
Nat Rev Microbiol. 2013 Jul;11(7):497-504
pubmed: 23748339
ACS Chem Biol. 2021 Oct 15;16(10):1829-1840
pubmed: 34590818
FEMS Microbiol Rev. 2018 Mar 1;42(2):146-164
pubmed: 29325042
Nat Rev Microbiol. 2018 Aug;16(8):457-470
pubmed: 29904082
Mucosal Immunol. 2017 Jan;10(1):91-103
pubmed: 27143302
Nat Commun. 2020 Feb 14;11(1):899
pubmed: 32060313
Appl Environ Microbiol. 2016 Jan 04;82(6):1686-1692
pubmed: 26729713
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9228-33
pubmed: 20439703
Mucosal Immunol. 2016 Sep;9(5):1218-33
pubmed: 26813339
FEBS Lett. 2010 Nov 5;584(21):4435-41
pubmed: 20932833
BMC Bioinformatics. 2014 Jan 13;15:7
pubmed: 24410852
Biochemistry. 2017 Aug 22;56(33):4293-4308
pubmed: 28826221
Nucleic Acids Res. 2021 Jan 8;49(D1):D480-D489
pubmed: 33237286
Microb Genom. 2020 Oct;6(10):
pubmed: 32667876
Front Microbiol. 2017 Mar 16;8:412
pubmed: 28360896
J Biol Chem. 2019 Nov 1;294(44):15973-15986
pubmed: 31501245
J Proteomics. 2021 Oct 30;249:104369
pubmed: 34481999
Biochemistry. 2019 Oct 15;58(41):4169-4182
pubmed: 31553576
Bioinformatics. 2018 Sep 15;34(18):3094-3100
pubmed: 29750242
Glycobiology. 2020 Aug 20;30(9):735-745
pubmed: 32149359
Curr Opin Struct Biol. 2021 Jun;68:26-40
pubmed: 33285501
Nat Rev Gastroenterol Hepatol. 2020 Oct;17(10):597-617
pubmed: 32710014
PLoS Biol. 2021 Dec 22;19(12):e3001498
pubmed: 34936658
Curr Opin Chem Biol. 2018 Dec;47:77-85
pubmed: 30268904
Nature. 2013 Oct 3;502(7469):96-9
pubmed: 23995682
Nat Genet. 2022 Feb;54(2):134-142
pubmed: 35115689
Environ Microbiol Rep. 2021 Oct;13(5):559-581
pubmed: 34036727
Nat Biotechnol. 2021 Jan;39(1):105-114
pubmed: 32690973
Nucleic Acids Res. 2018 Jul 2;46(W1):W95-W101
pubmed: 29771380
Nucleic Acids Res. 2014 Jan;42(Database issue):D490-5
pubmed: 24270786
Glycobiology. 2017 Jan;27(1):3-49
pubmed: 27558841