Iodination of PEGylated Polymers Counteracts the Inhibition of Fibrinogen Adsorption by PEG.
Journal
Langmuir : the ACS journal of surfaces and colloids
ISSN: 1520-5827
Titre abrégé: Langmuir
Pays: United States
ID NLM: 9882736
Informations de publication
Date de publication:
06 12 2022
06 12 2022
Historique:
pubmed:
18
11
2022
medline:
7
1
2023
entrez:
17
11
2022
Statut:
ppublish
Résumé
Poly(ethylene glycol), PEG, known to inhibit protein adsorption, is widely used on the surfaces of biomedical devices when biofilm formation is undesirable. Poly(desaminotyrosyl-tyrosine ethyl ester carbonate), PDTEC, PC for short, has been a promising coating polymer for insertion devices, and it has been anticipated that PEG plays a similar role if it is copolymerized with PC. Earlier studies show that no fibrinogen (Fg) is adsorbed onto PC polymers with PEG beyond the threshold weight percentage. This is attributed to the phase separation of PEG. Further, iodination of the PC units in the PC polymer, (I
Identifiants
pubmed: 36394992
doi: 10.1021/acs.langmuir.2c02019
doi:
Substances chimiques
Polymers
0
Fibrinogen
9001-32-5
Polyethylene Glycols
3WJQ0SDW1A
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM