Microglial WNT5A supports dendritic spines maturation and neuronal firing.
Microglia
Neural development
Synaptic transmission
WNT
WNT5A
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
10
06
2022
revised:
13
10
2022
accepted:
11
11
2022
pubmed:
18
11
2022
medline:
16
12
2022
entrez:
17
11
2022
Statut:
ppublish
Résumé
There is increasing evidence showing that microglia play a critical role in mediating synapse formation and spine growth, although the molecular mechanism remains elusive. Here, we demonstrate that the secreted morphogen WNT family member 5A (WNT5A) is the most abundant WNT expressed in microglia and that it promotes neuronal maturation. Co-culture of microglia with Thy1-YFP
Identifiants
pubmed: 36395958
pii: S0889-1591(22)00432-9
doi: 10.1016/j.bbi.2022.11.003
pmc: PMC10588768
mid: NIHMS1933366
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
403-413Subventions
Organisme : NIA NIH HHS
ID : R01 AG079859
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008541
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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