Th2 and metabolic responses to nematodes are independent of prolonged host microbiota abrogation.
FLIM
H. polygyrus
NAD(P)H
Th2 response
antibiotic
metabolism
microbiota
Journal
Parasite immunology
ISSN: 1365-3024
Titre abrégé: Parasite Immunol
Pays: England
ID NLM: 7910948
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
revised:
11
11
2022
received:
15
09
2022
accepted:
14
11
2022
pubmed:
18
11
2022
medline:
24
3
2023
entrez:
17
11
2022
Statut:
ppublish
Résumé
Antibiotic treatment can lead to elimination of both pathogenic bacteria and beneficial commensals, as well as to altered host immune responses. Here, we investigated the influence of prolonged antibiotic treatment (Abx) on effector, memory and recall Th2 immune responses during the primary infection, memory phase and secondary infection with the small intestinal nematode Heligmosomoides polygyrus. Abx treatment significantly reduced gut bacterial loads, but neither worm burdens, nor worm fecundity in primary infection were affected, only worm burdens in secondary infection were elevated in Abx treated mice. Abx mice displayed trends for elevated effector and memory Th2 responses during primary infection, but overall frequencies of Th2 cells in the siLP, PEC, mLN and in the spleen were similar between Abx treated and untreated groups. Gata3
Substances chimiques
Cytokines
0
Gata3 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12957Informations de copyright
© 2022 The Authors. Parasite Immunology published by John Wiley & Sons Ltd.
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