Exhaled breath condensate as bioanalyte: from collection considerations to biomarker sensing.
Breath
Engineering
Exhaled breath condensate
Face masks
Point-of-care
Sensing
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
17
10
2022
accepted:
08
11
2022
revised:
06
11
2022
pubmed:
18
11
2022
medline:
10
1
2023
entrez:
17
11
2022
Statut:
ppublish
Résumé
Since the SARS-CoV-2 pandemic, the potential of exhaled breath (EB) to provide valuable information and insight into the health status of a person has been revisited. Mass spectrometry (MS) has gained increasing attention as a powerful analytical tool for clinical diagnostics of exhaled breath aerosols (EBA) and exhaled breath condensates (EBC) due to its high sensitivity and specificity. Although MS will continue to play an important role in biomarker discovery in EB, its use in clinical setting is rather limited. EB analysis is moving toward online sampling with portable, room temperature operable, and inexpensive point-of-care devices capable of real-time measurements. This transition is happening due to the availability of highly performing biosensors and the use of wearable EB collection tools, mostly in the form of face masks. This feature article will outline the last developments in the field, notably the novel ways of EBA and EBC collection and the analytical aspects of the collected samples. The inherit non-invasive character of the sample collection approach might open new doors for efficient ways for a fast, non-invasive, and better diagnosis.
Identifiants
pubmed: 36396732
doi: 10.1007/s00216-022-04433-5
pii: 10.1007/s00216-022-04433-5
pmc: PMC9672542
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
27-34Informations de copyright
© 2022. Springer-Verlag GmbH Germany, part of Springer Nature.
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