Phosphatidylinositol 4,5-bisphosphate (PIP


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
17 11 2022
Historique:
received: 03 05 2022
accepted: 01 11 2022
entrez: 17 11 2022
pubmed: 18 11 2022
medline: 22 11 2022
Statut: epublish

Résumé

The plasmalemmal norepinephrine transporter (NET) regulates cardiovascular sympathetic activity by clearing extracellular norepinephrine in the synaptic cleft. Here, we investigate the subunit stoichiometry and function of NET using single-molecule fluorescence microscopy and flux assays. In particular, we show the effect of phosphatidylinositol 4,5-bisphosphate (PIP

Identifiants

pubmed: 36396757
doi: 10.1038/s42003-022-04210-1
pii: 10.1038/s42003-022-04210-1
pmc: PMC9672106
doi:

Substances chimiques

Norepinephrine Plasma Membrane Transport Proteins 0
Phosphatidylinositols 0
Inositol Phosphates 0
Norepinephrine X4W3ENH1CV

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1259

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
ID : Z1A DA000610
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
ID : Z1A DA000610
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
ID : Z1A DA000610

Informations de copyright

© 2022. The Author(s).

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Auteurs

Dino Luethi (D)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.
Institute of Applied Physics, TU Wien, Lehargasse 6, 1060, Vienna, Austria.

Julian Maier (J)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Deborah Rudin (D)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Dániel Szöllősi (D)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Thomas J F Angenoorth (TJF)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Stevan Stankovic (S)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Matthias Schittmayer (M)

Institute of Chemical Technologies and Analytics, TU Wien, Getreidemarkt 9, 1060, Vienna, Austria.

Isabella Burger (I)

Institute of Chemical Technologies and Analytics, TU Wien, Getreidemarkt 9, 1060, Vienna, Austria.

Jae-Won Yang (JW)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Kathrin Jaentsch (K)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Marion Holy (M)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Anand Kant Das (AK)

Institute of Applied Physics, TU Wien, Lehargasse 6, 1060, Vienna, Austria.
Physics Program, New York University Abu Dhabi, Saadiyat Island, 129188, Abu Dhabi, United Arab Emirates.

Mario Brameshuber (M)

Institute of Applied Physics, TU Wien, Lehargasse 6, 1060, Vienna, Austria.

Gisela Andrea Camacho-Hernandez (GA)

Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse - Intramural Research Program, Baltimore, MD, 21224, USA.

Andrea Casiraghi (A)

Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse - Intramural Research Program, Baltimore, MD, 21224, USA.
Department of Pharmaceutical Sciences, University of Milan, Via Luigi Mangiagalli 25, 20133, Milan, Italy.

Amy Hauck Newman (AH)

Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse - Intramural Research Program, Baltimore, MD, 21224, USA.

Oliver Kudlacek (O)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Ruth Birner-Gruenberger (R)

Institute of Chemical Technologies and Analytics, TU Wien, Getreidemarkt 9, 1060, Vienna, Austria.
Diagnostic and Research Institute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010, Graz, Austria.

Thomas Stockner (T)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Gerhard J Schütz (GJ)

Institute of Applied Physics, TU Wien, Lehargasse 6, 1060, Vienna, Austria. schuetz@iap.tuwien.ac.at.

Harald H Sitte (HH)

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria. harald.sitte@meduniwien.ac.at.

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Classifications MeSH