The use of carvone in consecutive patch testing.
contact allergy
fragrances
l-carvone
oral lichen
patch test
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
revised:
30
10
2022
received:
07
09
2022
accepted:
16
11
2022
pubmed:
19
11
2022
medline:
9
2
2023
entrez:
18
11
2022
Statut:
ppublish
Résumé
Carvone (l-carvone) is a mint-tasting flavour additive that most of us is exposed to and can cause allergic contact reactions. To analyse the frequency and the relevance of positive carvone reactions in a dermatitis population. A retrospective analysis of dermatitis patients consecutively tested with carvone from 2017 to 2021. Data were retrieved from the department's patch-test database. Of 3554 patients tested with carvone, 28 (0.79%) had a positive reaction. Carvone-positive patients had higher mean age, were significantly more likely female (p < 0.001) and had often an intraoral/lip involvement (p < 0.001). In the carvone-positive group, 50% (n = 14) had a relevant reaction, and in 4 of 14, the relevance was first revealed after test reading. Of the carvone-positive patients, 18 of 28 did not have a coexisting allergy to a fragrance/flavour allergen and of these 44% had a relevant allergy. The study suggests that a significant fraction of relevant carvone contact allergies may be overlooked if the allergen is not tested. Furthermore, as the exposure is widespread, inclusion of carvone in the Swedish baseline series may be justified even if the contact allergy prevalence is below 1%.
Sections du résumé
BACKGROUND
BACKGROUND
Carvone (l-carvone) is a mint-tasting flavour additive that most of us is exposed to and can cause allergic contact reactions.
OBJECTIVES
OBJECTIVE
To analyse the frequency and the relevance of positive carvone reactions in a dermatitis population.
METHOD
METHODS
A retrospective analysis of dermatitis patients consecutively tested with carvone from 2017 to 2021. Data were retrieved from the department's patch-test database.
RESULTS
RESULTS
Of 3554 patients tested with carvone, 28 (0.79%) had a positive reaction. Carvone-positive patients had higher mean age, were significantly more likely female (p < 0.001) and had often an intraoral/lip involvement (p < 0.001). In the carvone-positive group, 50% (n = 14) had a relevant reaction, and in 4 of 14, the relevance was first revealed after test reading. Of the carvone-positive patients, 18 of 28 did not have a coexisting allergy to a fragrance/flavour allergen and of these 44% had a relevant allergy.
CONCLUSIONS
CONCLUSIONS
The study suggests that a significant fraction of relevant carvone contact allergies may be overlooked if the allergen is not tested. Furthermore, as the exposure is widespread, inclusion of carvone in the Swedish baseline series may be justified even if the contact allergy prevalence is below 1%.
Identifiants
pubmed: 36399045
doi: 10.1111/cod.14249
pmc: PMC10098734
doi:
Substances chimiques
carvone
75GK9XIA8I
Allergens
0
Perfume
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
206-211Informations de copyright
© 2022 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
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