HIV Incidence, Recent HIV Infection, and Associated Factors, Kenya, 2007-2018.

HIV incidence estimation HIV surveillance Kenya antiretroviral treatment population surveys tests for recent infection

Journal

AIDS research and human retroviruses
ISSN: 1931-8405
Titre abrégé: AIDS Res Hum Retroviruses
Pays: United States
ID NLM: 8709376

Informations de publication

Date de publication:
02 2023
Historique:
pubmed: 20 11 2022
medline: 15 2 2023
entrez: 19 11 2022
Statut: ppublish

Résumé

Nationally representative surveys provide an opportunity to assess trends in recent human immunodeficiency virus (HIV) infection based on assays for recent HIV infection. We assessed HIV incidence in Kenya in 2018 and trends in recent HIV infection among adolescents and adults in Kenya using nationally representative household surveys conducted in 2007, 2012, and 2018. To assess trends, we defined a recent HIV infection testing algorithm (RITA) that classified as recently infected (<12 months) those HIV-positive participants that were recent on the HIV-1 limiting antigen (LAg)-avidity assay without evidence of antiretroviral use. We assessed factors associated with recent and long-term (≥12 months) HIV infection versus no infection using a multinomial logit model while accounting for complex survey design. Of 1,523 HIV-positive participants in 2018, 11 were classified as recent. Annual HIV incidence was 0.14% in 2018 [95% confidence interval (CI) 0.057-0.23], representing 35,900 (95% CI 16,300-55,600) new infections per year in Kenya among persons aged 15-64 years. The percentage of HIV infections that were determined to be recent was similar in 2007 and 2012 but fell significantly from 2012 to 2018 [adjusted odds ratio (aOR) = 0.31,

Identifiants

pubmed: 36401361
doi: 10.1089/AID.2022.0054
pmc: PMC9942172
doi:

Types de publication

Journal Article Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

57-67

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Auteurs

Peter Wesley Young (PW)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Maputo, Mozambique.

Paul Musingila (P)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Nairobi, Kenya.

Leonard Kingwara (L)

National AIDS & STI Control Programme, Ministry of Health, Nairobi, Kenya.

Andrew C Voetsch (AC)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Emily Zielinski-Gutierrez (E)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Nairobi, Kenya.
Central America Regional Office, U.S. Centers for Disease Control and Prevention, Guatemala City, Guatemala.

Marc Bulterys (M)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Nairobi, Kenya.

Andrea A Kim (AA)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Megan A Bronson (MA)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Bharat S Parekh (BS)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Trudy Dobbs (T)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Hetal Patel (H)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Giles Reid (G)

Survey Unit, ICAP at Columbia University, New York, New York, USA.

Thomas Achia (T)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Nairobi, Kenya.

Alfred Keter (A)

National AIDS & STI Control Programme, Ministry of Health, Nairobi, Kenya.

Samuel Mwalili (S)

Department of Statistics and Actuarial Sciences, Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.

Francis M Ogollah (FM)

Survey Unit, ICAP at Columbia University, New York, New York, USA.

Raphael Ondondo (R)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Nairobi, Kenya.

Herbert Longwe (H)

Survey Unit, ICAP at Columbia University, New York, New York, USA.

Duncan Chege (D)

Survey Unit, ICAP at Columbia University, New York, New York, USA.

Nancy Bowen (N)

National Public Health Laboratory, Ministry of Health, Nairobi, Kenya.

Mamo Umuro (M)

National Public Health Laboratory, Ministry of Health, Nairobi, Kenya.

Catherine Ngugi (C)

Ministry of Health, Nairobi, Kenya.

Jessica Justman (J)

Survey Unit, ICAP at Columbia University, New York, New York, USA.

Peter Cherutich (P)

Ministry of Health, Nairobi, Kenya.

Kevin M De Cock (KM)

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Nairobi, Kenya.

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