Immune regulation of poly unsaturated fatty acids and free fatty acid receptor 4.
Free fatty acid receptor
G-protein coupled receptor
immune regulation
organ transplantation
polyunsaturated fatty acid
Journal
The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
18
12
2021
revised:
24
09
2022
accepted:
10
11
2022
pubmed:
20
11
2022
medline:
11
1
2023
entrez:
19
11
2022
Statut:
ppublish
Résumé
Fatty acid metabolism contributes to energy supply and plays an important role in regulating immunity. Free fatty acids (FFAs) bind to free fatty acid receptors (FFARs) on the cell surface and mediate effects through the intra-cellular FFAR signaling pathways. FFAR4, also known as G-protein coupled receptor 120 (GPR120), has been identified as the primary receptor of omega-3 polyunsaturated fatty acids (ω-3 PUFAs). FFAR4 is a promising target for treating metabolic and inflammatory disorders due to its immune regulatory functions and the discovery of highly selective and efficient agonists. This review summarizes the reported immune regulatory functions of ω-3 PUFAs and FFAR4 in immune cells and immune-related diseases. We also speculate possible involvements of ω-3 PUFAs and FFAR4 in other types of inflammatory disorders.
Identifiants
pubmed: 36402250
pii: S0955-2863(22)00290-X
doi: 10.1016/j.jnutbio.2022.109222
pii:
doi:
Substances chimiques
Fatty Acids, Omega-3
0
Fatty Acids, Unsaturated
0
Receptors, G-Protein-Coupled
0
FFAR4 protein, human
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109222Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest.