Enduring impact of childhood adversity: Affective modulation of acoustic startle response during pregnancy and postpartum.
Acoustic startle response
Adverse childhood experiences
Early life stress
Perinatal
Postpartum
Pregnancy
Journal
Physiology & behavior
ISSN: 1873-507X
Titre abrégé: Physiol Behav
Pays: United States
ID NLM: 0151504
Informations de publication
Date de publication:
01 01 2023
01 01 2023
Historique:
received:
15
05
2022
revised:
09
10
2022
accepted:
11
11
2022
pmc-release:
01
01
2024
pubmed:
20
11
2022
medline:
6
12
2022
entrez:
19
11
2022
Statut:
ppublish
Résumé
Women with a history of adverse childhood experiences (ACEs) enter pregnancy and the postpartum with a physiologic system programmed by early life stress, potentially reflected in psychophysiologic reactivity. We enrolled pregnant, psychiatrically healthy women ≥18 years old. Using the ACE Questionnaire, women were categorized as high (≥2 ACEs; n = 77) or low ACE (<2 ACEs; n = 72). Participants completed an affective modulation of acoustic startle response (ASR) task during pregnancy and postpartum, in which ASR magnitude was measured while participants viewed pleasant, unpleasant, and neutral pictures. Two types of control trials were included (habituation trials presented at baseline and intertrial interval trials presented when no picture was present). Among high ACE women, ASR was significantly higher postpartum compared with pregnancy in the unpleasant (p = 0.002, β = 0.46, 95% CI [0.18, 0.74], χ Physiological reactivity increased in high ACE women from pregnancy to postpartum, but no change was observed in low ACE women.
Sections du résumé
BACKGROUND
Women with a history of adverse childhood experiences (ACEs) enter pregnancy and the postpartum with a physiologic system programmed by early life stress, potentially reflected in psychophysiologic reactivity.
METHODS
We enrolled pregnant, psychiatrically healthy women ≥18 years old. Using the ACE Questionnaire, women were categorized as high (≥2 ACEs; n = 77) or low ACE (<2 ACEs; n = 72). Participants completed an affective modulation of acoustic startle response (ASR) task during pregnancy and postpartum, in which ASR magnitude was measured while participants viewed pleasant, unpleasant, and neutral pictures. Two types of control trials were included (habituation trials presented at baseline and intertrial interval trials presented when no picture was present).
RESULTS
Among high ACE women, ASR was significantly higher postpartum compared with pregnancy in the unpleasant (p = 0.002, β = 0.46, 95% CI [0.18, 0.74], χ
CONCLUSIONS
Physiological reactivity increased in high ACE women from pregnancy to postpartum, but no change was observed in low ACE women.
Identifiants
pubmed: 36402424
pii: S0031-9384(22)00335-3
doi: 10.1016/j.physbeh.2022.114031
pmc: PMC9762518
mid: NIHMS1852200
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
114031Subventions
Organisme : NIMH NIH HHS
ID : P50 MH099910
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest L.H. consults to PureTech Health. C.N.E. consults to Asarina Pharma and Sage Therapeutics and receives research support from Sage Therapeutics. All other authors report no declarations of interest.
Références
Stress. 2015;18(4):367-80
pubmed: 26176590
Psychoneuroendocrinology. 2020 Sep;119:104710
pubmed: 32563173
Arch Womens Ment Health. 2012 Apr;15(2):87-94
pubmed: 22315106
J Neuroendocrinol. 2018 Feb;30(2):
pubmed: 29072794
Brain Behav Immun. 2019 Jan;75:240-250
pubmed: 30399404
Biol Psychiatry. 2011 Mar 15;69(6):549-55
pubmed: 21277566
Arch Womens Ment Health. 2015 Aug;18(4):639-48
pubmed: 25278341
Psychoneuroendocrinology. 2017 Oct;84:197-205
pubmed: 28755550
Psychoneuroendocrinology. 2008 Jan;33(1):100-7
pubmed: 18037247
Brain Behav Immun Health. 2021 Jun 01;15:100280
pubmed: 34589780
Pharmacol Biochem Behav. 2009 Jun;92(4):608-13
pubmed: 19268499
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
Future Cardiol. 2014 Nov;10(6):759-68
pubmed: 25495817
Psychoneuroendocrinology. 2009 Jul;34(6):844-58
pubmed: 19181453
Psychophysiology. 2008 Sep;45(5):876-82
pubmed: 18665868
Psychoneuroendocrinology. 2015 Oct;60:217-23
pubmed: 26189199
Pharmacol Biochem Behav. 2001 Feb;68(2):203-10
pubmed: 11267624
Psychoneuroendocrinology. 2011 Sep;36(8):1184-92
pubmed: 21435793
Clin Psychol Sci. 2014 Mar 1;2(2):202-213
pubmed: 25473591
J Neuroendocrinol. 2008 Jun;20(6):764-76
pubmed: 18601699
J Neurosci. 2004 Nov 10;24(45):10280-7
pubmed: 15537900
Neuropsychopharmacology. 2010 Mar;35(4):929-37
pubmed: 19956084
Horm Behav. 2017 Aug;94:97-105
pubmed: 28676251
Psychol Bull. 2011 Nov;137(6):959-97
pubmed: 21787044
Psychoneuroendocrinology. 2003 Oct;28(7):916-31
pubmed: 12892658
Biol Psychiatry. 2017 Apr 15;81(8):693-701
pubmed: 27776734
J Perinatol. 2018 Aug;38(8):973-981
pubmed: 29795321
Clin Infect Dis. 2014 Dec 15;59 Suppl 7:S400-7
pubmed: 25425718
Br J Psychiatry. 1990 Aug;157:288-90
pubmed: 2224383
J Comp Neurol. 1990 Dec 22;302(4):697-706
pubmed: 1707064
Int J Environ Res Public Health. 2020 Sep 23;17(19):
pubmed: 32977397
Am J Reprod Immunol. 2021 May;85(5):e13366
pubmed: 33099840
Biol Psychiatry. 2019 Jan 15;85(2):97-106
pubmed: 30314641
Neuropsychopharmacology. 2017 Jul;42(8):1670-1678
pubmed: 28094283
Neuropsychopharmacology. 2007 May;32(5):1021-31
pubmed: 17047669
Depress Anxiety. 2009;26(11):1018-26
pubmed: 19691032
Br J Soc Clin Psychol. 1967 Dec;6(4):278-96
pubmed: 6080235
Psychophysiology. 2001 Mar;38(2):267-74
pubmed: 11347872
Mol Psychiatry. 2008 Mar;13(3):325-33
pubmed: 17579609
Front Neuroendocrinol. 2014 Apr;35(2):197-220
pubmed: 24246855
Biol Psychiatry. 2012 Feb 15;71(4):286-93
pubmed: 22112927
Biol Psychol. 2017 Feb;123:177-186
pubmed: 28027936
Biol Psychiatry. 2013 Jun 1;73(11):1045-53
pubmed: 23348009
Psychoneuroendocrinology. 2019 Aug;106:1-8
pubmed: 30927623
Neurosci Biobehav Rev. 2005 Apr;29(2):295-312
pubmed: 15811500
Psychoneuroendocrinology. 2010 Jun;35(5):686-93
pubmed: 19931984
Neuropsychopharmacology. 2010 Jan;35(1):105-35
pubmed: 19693004
Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1312-9
pubmed: 22529357
Dev Psychobiol. 2021 Mar;63(2):305-319
pubmed: 32572946
Schizophr Res. 2018 Aug;198:6-15
pubmed: 28549722
Front Behav Neurosci. 2015 Aug 04;9:205
pubmed: 26300750
Proc Natl Acad Sci U S A. 2012 Oct 16;109 Suppl 2:17180-5
pubmed: 23045648
Brain Behav Immun. 2017 Oct;65:11-19
pubmed: 28450221
Neuropsychopharmacology. 2007 Oct;32(10):2190-8
pubmed: 17314917
Behav Brain Res. 2020 Apr 6;383:112513
pubmed: 31991179
J Psychosom Res. 2013 Oct;75(4):305-13
pubmed: 24119935
Neuroimage. 2019 Jan 15;185:825-835
pubmed: 29654875
Behav Brain Res. 2014 Nov 1;274:326-33
pubmed: 25151928
Eur Neuropsychopharmacol. 2014 Nov;24(11):1828-35
pubmed: 25262177
J Behav Ther Exp Psychiatry. 1994 Mar;25(1):49-59
pubmed: 7962581
J Pediatr Gastroenterol Nutr. 2016 Jan;62(1):180-2
pubmed: 26418210
Br J Psychiatry. 1987 Jun;150:782-6
pubmed: 3651732
Int J Psychophysiol. 2002 Feb;43(2):191-6
pubmed: 11809522
Clin Neurophysiol. 2003 Sep;114(9):1557-79
pubmed: 12948786
Am J Prev Med. 1998 May;14(4):245-58
pubmed: 9635069
J Clin Psychiatry. 2017 Mar;78(3):e298-e307
pubmed: 28394509
Biol Psychol. 2006 Mar;71(3):303-11
pubmed: 16054283
Brain Behav Immun. 2017 Mar;61:176-183
pubmed: 27884623
J Neuroendocrinol. 1995 Mar;7(3):171-7
pubmed: 7606242
Psychiatry Res. 2010 Jul 30;178(2):236-43
pubmed: 20483176
Stress. 2011 Jan;14(1):6-12
pubmed: 20666638
Curr Psychiatry Rep. 2018 May 18;20(6):40
pubmed: 29777410
Eur Neuropsychopharmacol. 2016 Apr;26(4):767-76
pubmed: 26857197
Psychophysiology. 2016 Sep;53(9):1377-85
pubmed: 27237725
Behav Brain Res. 2018 Oct 1;351:178-187
pubmed: 29885381
Cochrane Database Syst Rev. 2018 Nov 15;11:CD003402
pubmed: 30480773
J Abnorm Psychol. 2007 May;116(2):352-61
pubmed: 17516767